Pharmacokinetics of amikacin in children undergoing continuous ambulatory peritoneal dialysis

Serife Eti, A. Nayir, S. Emre, A. Sirin, F. Tanman

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of amikacin were investigated in 3 stable children undergoing continuous ambulatory peritoneal dialysis (CAPD). Each patient was studied after the administration of 2-3 mg/kg amikacin both the intravenous and intraperitoneal routes allowing at least 10 days washout period between doses. After intraperitoneal instillation of amikacin, the antibiotic amikacin appeared in the serum within 15 minutes. The reaction of the intraperitoneal dose absorbed into systemic circulation was found to be between 0.42 to 0.95. When the same dose of amikacin was injected intravenously only a small amount of drug was present in peritoneal fluid for a brief period of a time. Thus, these data suggest that amikacin is absorbed from peritoneal fluid into the circulation, but reverse exchange is negligible. Since instillation of amikacin by intraperitoneal route may allow rapid absorption, periodic control of serum amikacin level is recommended.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalMedical Bulletin of Istanbul Medical Faculty
Volume27
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Amikacin
Continuous Ambulatory Peritoneal Dialysis
Pharmacokinetics
Ascitic Fluid
Serum
Anti-Bacterial Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pharmacokinetics of amikacin in children undergoing continuous ambulatory peritoneal dialysis. / Eti, Serife; Nayir, A.; Emre, S.; Sirin, A.; Tanman, F.

In: Medical Bulletin of Istanbul Medical Faculty, Vol. 27, No. 2, 1994, p. 6-9.

Research output: Contribution to journalArticle

@article{039e3bb94e0448af8112939a82dc0f44,
title = "Pharmacokinetics of amikacin in children undergoing continuous ambulatory peritoneal dialysis",
abstract = "The pharmacokinetics of amikacin were investigated in 3 stable children undergoing continuous ambulatory peritoneal dialysis (CAPD). Each patient was studied after the administration of 2-3 mg/kg amikacin both the intravenous and intraperitoneal routes allowing at least 10 days washout period between doses. After intraperitoneal instillation of amikacin, the antibiotic amikacin appeared in the serum within 15 minutes. The reaction of the intraperitoneal dose absorbed into systemic circulation was found to be between 0.42 to 0.95. When the same dose of amikacin was injected intravenously only a small amount of drug was present in peritoneal fluid for a brief period of a time. Thus, these data suggest that amikacin is absorbed from peritoneal fluid into the circulation, but reverse exchange is negligible. Since instillation of amikacin by intraperitoneal route may allow rapid absorption, periodic control of serum amikacin level is recommended.",
author = "Serife Eti and A. Nayir and S. Emre and A. Sirin and F. Tanman",
year = "1994",
language = "English (US)",
volume = "27",
pages = "6--9",
journal = "Medical Bulletin of Istanbul Medical Faculty",
issn = "0378-6358",
publisher = "University of Istanbul",
number = "2",

}

TY - JOUR

T1 - Pharmacokinetics of amikacin in children undergoing continuous ambulatory peritoneal dialysis

AU - Eti, Serife

AU - Nayir, A.

AU - Emre, S.

AU - Sirin, A.

AU - Tanman, F.

PY - 1994

Y1 - 1994

N2 - The pharmacokinetics of amikacin were investigated in 3 stable children undergoing continuous ambulatory peritoneal dialysis (CAPD). Each patient was studied after the administration of 2-3 mg/kg amikacin both the intravenous and intraperitoneal routes allowing at least 10 days washout period between doses. After intraperitoneal instillation of amikacin, the antibiotic amikacin appeared in the serum within 15 minutes. The reaction of the intraperitoneal dose absorbed into systemic circulation was found to be between 0.42 to 0.95. When the same dose of amikacin was injected intravenously only a small amount of drug was present in peritoneal fluid for a brief period of a time. Thus, these data suggest that amikacin is absorbed from peritoneal fluid into the circulation, but reverse exchange is negligible. Since instillation of amikacin by intraperitoneal route may allow rapid absorption, periodic control of serum amikacin level is recommended.

AB - The pharmacokinetics of amikacin were investigated in 3 stable children undergoing continuous ambulatory peritoneal dialysis (CAPD). Each patient was studied after the administration of 2-3 mg/kg amikacin both the intravenous and intraperitoneal routes allowing at least 10 days washout period between doses. After intraperitoneal instillation of amikacin, the antibiotic amikacin appeared in the serum within 15 minutes. The reaction of the intraperitoneal dose absorbed into systemic circulation was found to be between 0.42 to 0.95. When the same dose of amikacin was injected intravenously only a small amount of drug was present in peritoneal fluid for a brief period of a time. Thus, these data suggest that amikacin is absorbed from peritoneal fluid into the circulation, but reverse exchange is negligible. Since instillation of amikacin by intraperitoneal route may allow rapid absorption, periodic control of serum amikacin level is recommended.

UR - http://www.scopus.com/inward/record.url?scp=0028674026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028674026&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028674026

VL - 27

SP - 6

EP - 9

JO - Medical Bulletin of Istanbul Medical Faculty

JF - Medical Bulletin of Istanbul Medical Faculty

SN - 0378-6358

IS - 2

ER -