Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan, Chuong Dinh, Jining Zhang, Chou Pong Pau, Janet M. Mcnicholl, Yungtai Lo, Betsy Herold, Ryan Teller, Patrick Kiser, James M. Smith

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalJournal of Medical Primatology
Volume43
Issue number5
DOIs
StatePublished - Oct 1 2014

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Tenofovir
Macaca nemestrina
Macaca
pharmacokinetics
Pharmacokinetics
secretion
Safety
methodology
fumarates
tissues

Keywords

  • HIV microbicide
  • Non-human primates
  • Pre-exposure prophylaxis
  • Sustained release

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use. / Srinivasan, Priya; Dinh, Chuong; Zhang, Jining; Pau, Chou Pong; Mcnicholl, Janet M.; Lo, Yungtai; Herold, Betsy; Teller, Ryan; Kiser, Patrick; Smith, James M.

In: Journal of Medical Primatology, Vol. 43, No. 5, 01.10.2014, p. 364-369.

Research output: Contribution to journalArticle

Srinivasan, Priya ; Dinh, Chuong ; Zhang, Jining ; Pau, Chou Pong ; Mcnicholl, Janet M. ; Lo, Yungtai ; Herold, Betsy ; Teller, Ryan ; Kiser, Patrick ; Smith, James M. / Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use. In: Journal of Medical Primatology. 2014 ; Vol. 43, No. 5. pp. 364-369.
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