Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan; Chuong Dinh; Jining Zhang; Chou Pong Pau; Janet M. Mcnicholl; Yungtai Lo; Betsy C. Herold; Ryan Teller; Patrick Kiser; James M. Smith

doi:10.1111/jmp.12119

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan, Chuong Dinh, Jining Zhang, Chou Pong Pau, Janet M. Mcnicholl, Yungtai Lo, Betsy C. Herold, Ryan Teller, Patrick Kiser, James M. Smith

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

Original language	English (US)
Pages (from-to)	364-369
Number of pages	6
Journal	Journal of Medical Primatology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1111/jmp.12119
State	Published - Oct 1 2014

Keywords

HIV microbicide
Non-human primates
Pre-exposure prophylaxis
Sustained release

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/jmp.12119

Cite this

@article{d56ce959485f4127840fd7db675ca879,

title = "Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use",

abstract = "Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.",

keywords = "HIV microbicide, Non-human primates, Pre-exposure prophylaxis, Sustained release",

author = "Priya Srinivasan and Chuong Dinh and Jining Zhang and Pau, {Chou Pong} and Mcnicholl, {Janet M.} and Yungtai Lo and Herold, {Betsy C.} and Ryan Teller and Patrick Kiser and Smith, {James M.}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons A/S435 October 2014.",

year = "2014",

month = oct,

day = "1",

doi = "10.1111/jmp.12119",

language = "English (US)",

volume = "43",

pages = "364--369",

journal = "Journal of Medical Primatology",

issn = "0047-2565",

publisher = "Blackwell Munksgaard",

number = "5",

}

TY - JOUR

T1 - Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

AU - Srinivasan, Priya

AU - Dinh, Chuong

AU - Zhang, Jining

AU - Pau, Chou Pong

AU - Mcnicholl, Janet M.

AU - Lo, Yungtai

AU - Herold, Betsy C.

AU - Teller, Ryan

AU - Kiser, Patrick

AU - Smith, James M.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

AB - Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

KW - HIV microbicide

KW - Non-human primates

KW - Pre-exposure prophylaxis

KW - Sustained release

UR - http://www.scopus.com/inward/record.url?scp=84927783919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927783919&partnerID=8YFLogxK

U2 - 10.1111/jmp.12119

DO - 10.1111/jmp.12119

M3 - Article

C2 - 25379594

AN - SCOPUS:84927783919

SN - 0047-2565

VL - 43

SP - 364

EP - 369

JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

IS - 5

ER -