Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan, Chuong Dinh, Jining Zhang, Chou Pong Pau, Janet M. Mcnicholl, Yungtai Lo, Betsy C. Herold, Ryan Teller, Patrick Kiser, James M. Smith

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalJournal of Medical Primatology
Volume43
Issue number5
DOIs
StatePublished - Oct 1 2014

Keywords

  • HIV microbicide
  • Non-human primates
  • Pre-exposure prophylaxis
  • Sustained release

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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