Pharmacogenetics of morphine: Potential implications in sickle cell disease

Deepika S. Darbari; Caterina P. Minniti; Sohail Rana; John Van Den Anker

doi:10.1002/ajh.21027

Pharmacogenetics of morphine: Potential implications in sickle cell disease

Deepika S. Darbari, Caterina P. Minniti, Sohail Rana, John Van Den Anker

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Morphine is frequently used to treat painful episodes associated with sickle cell disease (SCD) but may fail to provide adequate analgesia in many patients. This concise review focuses on unique disease related changes in physiologic variables associated with SCD that impacts pharmacokinetics and pharmacodynamics of morphine and may contribute to the variability in analgesia. Emerging evidence suggests that the allelic variants in the genes involving the opioid (UGT2B7, OPRM1, and ABCB1 genes) and nonopioid system (COMT gene) can alter the efficacy of morphine.

Original language	English (US)
Pages (from-to)	233-236
Number of pages	4
Journal	American Journal of Hematology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1002/ajh.21027
State	Published - Mar 2008
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1002/ajh.21027

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abstract = "Morphine is frequently used to treat painful episodes associated with sickle cell disease (SCD) but may fail to provide adequate analgesia in many patients. This concise review focuses on unique disease related changes in physiologic variables associated with SCD that impacts pharmacokinetics and pharmacodynamics of morphine and may contribute to the variability in analgesia. Emerging evidence suggests that the allelic variants in the genes involving the opioid (UGT2B7, OPRM1, and ABCB1 genes) and nonopioid system (COMT gene) can alter the efficacy of morphine.",

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AU - Darbari, Deepika S.

AU - Minniti, Caterina P.

AU - Rana, Sohail

AU - Van Den Anker, John

PY - 2008/3

Y1 - 2008/3

N2 - Morphine is frequently used to treat painful episodes associated with sickle cell disease (SCD) but may fail to provide adequate analgesia in many patients. This concise review focuses on unique disease related changes in physiologic variables associated with SCD that impacts pharmacokinetics and pharmacodynamics of morphine and may contribute to the variability in analgesia. Emerging evidence suggests that the allelic variants in the genes involving the opioid (UGT2B7, OPRM1, and ABCB1 genes) and nonopioid system (COMT gene) can alter the efficacy of morphine.

AB - Morphine is frequently used to treat painful episodes associated with sickle cell disease (SCD) but may fail to provide adequate analgesia in many patients. This concise review focuses on unique disease related changes in physiologic variables associated with SCD that impacts pharmacokinetics and pharmacodynamics of morphine and may contribute to the variability in analgesia. Emerging evidence suggests that the allelic variants in the genes involving the opioid (UGT2B7, OPRM1, and ABCB1 genes) and nonopioid system (COMT gene) can alter the efficacy of morphine.

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Pharmacogenetics of morphine: Potential implications in sickle cell disease

Abstract

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