Pharmacogenetics of morphine: Potential implications in sickle cell disease

Deepika S. Darbari, Caterina P. Minniti, Sohail Rana, John Van Den Anker

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Morphine is frequently used to treat painful episodes associated with sickle cell disease (SCD) but may fail to provide adequate analgesia in many patients. This concise review focuses on unique disease related changes in physiologic variables associated with SCD that impacts pharmacokinetics and pharmacodynamics of morphine and may contribute to the variability in analgesia. Emerging evidence suggests that the allelic variants in the genes involving the opioid (UGT2B7, OPRM1, and ABCB1 genes) and nonopioid system (COMT gene) can alter the efficacy of morphine.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalAmerican Journal of Hematology
Volume83
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Pharmacogenetics
Sickle Cell Anemia
Morphine
Analgesia
Genes
Opioid Analgesics
Pharmacokinetics

ASJC Scopus subject areas

  • Hematology

Cite this

Pharmacogenetics of morphine : Potential implications in sickle cell disease. / Darbari, Deepika S.; Minniti, Caterina P.; Rana, Sohail; Van Den Anker, John.

In: American Journal of Hematology, Vol. 83, No. 3, 03.2008, p. 233-236.

Research output: Contribution to journalReview article

Darbari, Deepika S. ; Minniti, Caterina P. ; Rana, Sohail ; Van Den Anker, John. / Pharmacogenetics of morphine : Potential implications in sickle cell disease. In: American Journal of Hematology. 2008 ; Vol. 83, No. 3. pp. 233-236.
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