Phagocytic signaling strategies: Fcγ receptor-mediated phagocytosis as a model system

Dianne Cox, Steven Greenberg

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 μ m. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fcγ Rs).

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalSeminars in Immunology
Volume13
Issue number6
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Actin
  • Fcreceptors
  • Syk
  • Tyrosine kinase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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