Persulfated molecular umbrellas as anti-HIV and anti-HSV agents

Bingwen Jing, Vaclav Janout, Betsy Herold, Mary E. Klotman, Taylor Heald, Steven L. Regen

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A series of persulfated molecular umbrellas have been synthesized from putrescine, spermidine, spermine, lysine, and cholic acid (1a, 2a, 3a, 4a, and 5a) and their anti-HIV and anti-HSV activities determined. Despite it size, the most active of these conjugates (5a) was able to cross phospholipid bilayers made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG). The unique combination of anti-viral activity, an ability to cross hydrophobic barriers, a lack of cytotoxicity, and a simple three-step synthesis from biogenic starting material suggests that 5a and related conjugates may be exploitable as a novel class of anti-viral agents for systemic and topical applications.

Original languageEnglish (US)
Pages (from-to)15930-15931
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number49
DOIs
StatePublished - Dec 15 2004
Externally publishedYes

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Antiviral agents
Anti-HIV Agents
Cholic Acid
Phosphatidylglycerols
Putrescine
Spermidine
Phosphorylcholine
Spermine
Phospholipids
Cytotoxicity
Lysine
HIV
Acids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Persulfated molecular umbrellas as anti-HIV and anti-HSV agents. / Jing, Bingwen; Janout, Vaclav; Herold, Betsy; Klotman, Mary E.; Heald, Taylor; Regen, Steven L.

In: Journal of the American Chemical Society, Vol. 126, No. 49, 15.12.2004, p. 15930-15931.

Research output: Contribution to journalArticle

Jing, B, Janout, V, Herold, B, Klotman, ME, Heald, T & Regen, SL 2004, 'Persulfated molecular umbrellas as anti-HIV and anti-HSV agents', Journal of the American Chemical Society, vol. 126, no. 49, pp. 15930-15931. https://doi.org/10.1021/ja044400o
Jing, Bingwen ; Janout, Vaclav ; Herold, Betsy ; Klotman, Mary E. ; Heald, Taylor ; Regen, Steven L. / Persulfated molecular umbrellas as anti-HIV and anti-HSV agents. In: Journal of the American Chemical Society. 2004 ; Vol. 126, No. 49. pp. 15930-15931.
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