Perspectives on the Trypanosoma cruzi-host cell receptor interactions

Fernando Villalta, Julio Scharfstein, Anthony W. Ashton, Kevin M. Tyler, Fangxia Guan, Shankar Mukherjee, Maria F. Lima, Sandra Alvarez, Louis M. Weiss, Huan Huang, Fabiana S. MacHado, Herbert B. Tanowitz

Research output: Contribution to journalReview article

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Abstract

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1251-1260
Number of pages10
JournalParasitology research
Volume104
Issue number6
DOIs
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

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    Villalta, F., Scharfstein, J., Ashton, A. W., Tyler, K. M., Guan, F., Mukherjee, S., Lima, M. F., Alvarez, S., Weiss, L. M., Huang, H., MacHado, F. S., & Tanowitz, H. B. (2009). Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitology research, 104(6), 1251-1260. https://doi.org/10.1007/s00436-009-1383-3