Perspectives on NMR in drug discovery: A technique comes of age

Maurizio Pellecchia, Ivano Bertini, David Cowburn, Claudio Dalvit, Ernest Giralt, Wolfgang Jahnke, Thomas L. James, Steve W. Homans, Horst Kessler, Claudio Luchinat, Bernd Meyer, Hartmut Oschkinat, Jeff Peng, Harald Schwalbe, Gregg Siegal

Research output: Contribution to journalArticle

283 Scopus citations

Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

Original languageEnglish (US)
Pages (from-to)738-745
Number of pages8
JournalNature Reviews Drug Discovery
Volume7
Issue number9
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T. L., Homans, S. W., Kessler, H., Luchinat, C., Meyer, B., Oschkinat, H., Peng, J., Schwalbe, H., & Siegal, G. (2008). Perspectives on NMR in drug discovery: A technique comes of age. Nature Reviews Drug Discovery, 7(9), 738-745. https://doi.org/10.1038/nrd2606