Perspectives for Preventive and Therapeutic HPV Vaccines

Ken Yu Lin, Kimberley Doolan, Chien Fu Hung, T. C. Wu

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Human Papillomavirus (HPV) has been associated with several human cancers, including cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck cancers. Thus effective vaccination against HPV provides an opportunity to reduce the morbidity and mortality associated with HPV. The Food and Drug Administration of the United States has approved two preventive vaccines to limit the spread of HPV. However, these are unlikely to impact upon HPV prevalence and cervical cancer rates for many years. Furthermore, preventive vaccines do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions. In order to further impact upon the burden of HPV infections worldwide, therapeutic vaccines are being developed. These vaccines aim to generate a cell-mediated immune response to infected cells. This review discusses current preventive and therapeutic HPV vaccines and their future directions.

Original languageEnglish (US)
Pages (from-to)4-24
Number of pages21
JournalJournal of the Formosan Medical Association
Volume109
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Papillomavirus Vaccines
Vaccines
Papillomavirus Infections
Therapeutics
Uterine Cervical Neoplasms
Vaginal Neoplasms
Vulvar Neoplasms
Anus Neoplasms
Therapeutic Uses
United States Food and Drug Administration
Head and Neck Neoplasms
Vaccination
Morbidity

Keywords

  • cervical cancer
  • HPV
  • HPV E6 E7
  • HPV L1 L2
  • preventive vaccines
  • therapeutic vaccines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Perspectives for Preventive and Therapeutic HPV Vaccines. / Lin, Ken Yu; Doolan, Kimberley; Hung, Chien Fu; Wu, T. C.

In: Journal of the Formosan Medical Association, Vol. 109, No. 1, 01.01.2010, p. 4-24.

Research output: Contribution to journalReview article

Lin, Ken Yu ; Doolan, Kimberley ; Hung, Chien Fu ; Wu, T. C. / Perspectives for Preventive and Therapeutic HPV Vaccines. In: Journal of the Formosan Medical Association. 2010 ; Vol. 109, No. 1. pp. 4-24.
@article{c32da80ecfd34e8fa0f5d0012fd2d3a5,
title = "Perspectives for Preventive and Therapeutic HPV Vaccines",
abstract = "Human Papillomavirus (HPV) has been associated with several human cancers, including cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck cancers. Thus effective vaccination against HPV provides an opportunity to reduce the morbidity and mortality associated with HPV. The Food and Drug Administration of the United States has approved two preventive vaccines to limit the spread of HPV. However, these are unlikely to impact upon HPV prevalence and cervical cancer rates for many years. Furthermore, preventive vaccines do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions. In order to further impact upon the burden of HPV infections worldwide, therapeutic vaccines are being developed. These vaccines aim to generate a cell-mediated immune response to infected cells. This review discusses current preventive and therapeutic HPV vaccines and their future directions.",
keywords = "cervical cancer, HPV, HPV E6 E7, HPV L1 L2, preventive vaccines, therapeutic vaccines",
author = "Lin, {Ken Yu} and Kimberley Doolan and Hung, {Chien Fu} and Wu, {T. C.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1016/S0929-6646(10)60017-4",
language = "English (US)",
volume = "109",
pages = "4--24",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Excerpta Medica Asia Ltd.",
number = "1",

}

TY - JOUR

T1 - Perspectives for Preventive and Therapeutic HPV Vaccines

AU - Lin, Ken Yu

AU - Doolan, Kimberley

AU - Hung, Chien Fu

AU - Wu, T. C.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Human Papillomavirus (HPV) has been associated with several human cancers, including cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck cancers. Thus effective vaccination against HPV provides an opportunity to reduce the morbidity and mortality associated with HPV. The Food and Drug Administration of the United States has approved two preventive vaccines to limit the spread of HPV. However, these are unlikely to impact upon HPV prevalence and cervical cancer rates for many years. Furthermore, preventive vaccines do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions. In order to further impact upon the burden of HPV infections worldwide, therapeutic vaccines are being developed. These vaccines aim to generate a cell-mediated immune response to infected cells. This review discusses current preventive and therapeutic HPV vaccines and their future directions.

AB - Human Papillomavirus (HPV) has been associated with several human cancers, including cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck cancers. Thus effective vaccination against HPV provides an opportunity to reduce the morbidity and mortality associated with HPV. The Food and Drug Administration of the United States has approved two preventive vaccines to limit the spread of HPV. However, these are unlikely to impact upon HPV prevalence and cervical cancer rates for many years. Furthermore, preventive vaccines do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions. In order to further impact upon the burden of HPV infections worldwide, therapeutic vaccines are being developed. These vaccines aim to generate a cell-mediated immune response to infected cells. This review discusses current preventive and therapeutic HPV vaccines and their future directions.

KW - cervical cancer

KW - HPV

KW - HPV E6 E7

KW - HPV L1 L2

KW - preventive vaccines

KW - therapeutic vaccines

UR - http://www.scopus.com/inward/record.url?scp=76849115615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76849115615&partnerID=8YFLogxK

U2 - 10.1016/S0929-6646(10)60017-4

DO - 10.1016/S0929-6646(10)60017-4

M3 - Review article

VL - 109

SP - 4

EP - 24

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 1

ER -