TY - JOUR
T1 - Personality disorders and the trimensional personality questionnaire factors in major depressive disorder
AU - Farabaugh, Amy
AU - Ongur, Dost
AU - Fava, Maurizio
AU - Hamill, Sarah K.
AU - Burns, Alana M.
AU - Alpert, Jonathan
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/11
Y1 - 2005/11
N2 - We assessed the potential relationship between personality disorder (PD) clusters, as assessed by the SCID-II, and temperamental traits assessed by the Tridimensional Personality Questionnaire (TPQ) among a well-characterized, unmedicated cohort of outpatients with major depressive disorder (MDD). The TPQ and SCID-II were administered to 263 depressed outpatients (mean age = 39.9 ± 10.5 years; women = 139, 53%; initial 17-item Hamilton Rating Scale for Depression = 19.6 ± 3.4) who currently met criteria for MDD and who were enrolled in an 8-week treatment trial. The multiple linear regression method was used to evaluate the relationship between TPQ factors and personality disorder clusters, controlling for age, gender, and initial 17-item Hamilton Rating Scale for Depression score as necessary. Among outpatients with MDD, meeting criteria for a Cluster A PD diagnosis was related to high harm avoidance (HA) scores, as well as low reward dependence and novelty seeking (NS) scores. Additionally, high HA scores were associated with meeting criteria for a Cluster C PD diagnosis, while high NS scores were associated with meeting criteria for a Cluster B PD diagnosis. Certain temperament traits, especially HA and NS, appear to be associated with specific patterns of personality clusters among depressed patients.
AB - We assessed the potential relationship between personality disorder (PD) clusters, as assessed by the SCID-II, and temperamental traits assessed by the Tridimensional Personality Questionnaire (TPQ) among a well-characterized, unmedicated cohort of outpatients with major depressive disorder (MDD). The TPQ and SCID-II were administered to 263 depressed outpatients (mean age = 39.9 ± 10.5 years; women = 139, 53%; initial 17-item Hamilton Rating Scale for Depression = 19.6 ± 3.4) who currently met criteria for MDD and who were enrolled in an 8-week treatment trial. The multiple linear regression method was used to evaluate the relationship between TPQ factors and personality disorder clusters, controlling for age, gender, and initial 17-item Hamilton Rating Scale for Depression score as necessary. Among outpatients with MDD, meeting criteria for a Cluster A PD diagnosis was related to high harm avoidance (HA) scores, as well as low reward dependence and novelty seeking (NS) scores. Additionally, high HA scores were associated with meeting criteria for a Cluster C PD diagnosis, while high NS scores were associated with meeting criteria for a Cluster B PD diagnosis. Certain temperament traits, especially HA and NS, appear to be associated with specific patterns of personality clusters among depressed patients.
KW - Depression
KW - Personality disorders
KW - TPQ
KW - Temperament
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UR - http://www.scopus.com/inward/citedby.url?scp=27744576771&partnerID=8YFLogxK
U2 - 10.1097/01.nmd.0000185873.36662.76
DO - 10.1097/01.nmd.0000185873.36662.76
M3 - Article
C2 - 16260931
AN - SCOPUS:27744576771
SN - 0022-3018
VL - 193
SP - 747
EP - 750
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 11
ER -