Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats

Mikhail V. Pletnikov, Steven A. Rubin, Gary J. Schwartz, Timothy H. Moran, Thomas J. Sobotka, Kathryn M. Carbone

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum. When mature, neonatally BDV-infected rats show extreme locomotor hyperactivity and reduced freezing behavior in novel environments. Traditional interpretation of both of these behavioral abnormalities would suggest decreased anxiety in infected rats compared to normal animals. However, it also possible that the locomotor hyperactivity in infected rats reflects higher rather than reduced anxiety, and is the result of increased escape responses to aversive stimuli. The present experiments were undertaken to test a hypothesis about elevated anxiety in neonatally BDV-infected adult Lewis rats by studying their species-specific fear-related responses. Compared to normal subjects, BDV-infected rats exhibited locomotor hyperactivity and elevated defecation in a highly aversive, brightly lit open field. As expected, in a less aversive, dimly lit open field, uninfected controls increased ambulation, whereas infected rats significantly decreased locomotor activity and defecation. Unlike uninfected rats, BDV-infected rats exhibited an attenuated freezing response immediately after loud auditory stimuli. On the contrary, immediate freezing responses following footshock were comparable in the two groups of animals indicating an intact ability to freeze in BDV-infected rats. Despite a decreased baseline startle responsiveness, BDV-infected rats demonstrated increased sensitization of the startle response by preceding footshocks, suggesting a tendency toward elevated escape responses. Compared to normal subjects, BDV-infected rats showed decreased conditional freezing and elevated conditional defecation response in the context previously paired with aversive stimulation indicating sparing of an autonomic component of fear conditioning. The findings indicate that neonatally BDV-infected adult rats are hyperreactive to aversive stimuli, possibly as a result of chronic emotional abnormalities. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)823-831
Number of pages9
JournalPhysiology and Behavior
Volume66
Issue number5
DOIs
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Infant, Newborn, Diseases
Borna disease virus
Virus Diseases
Brain
Freezing
Defecation
Anxiety
Fear
Startle Reflex
Parahippocampal Gyrus
Aptitude
Dentate Gyrus

Keywords

  • Anxiety
  • Borna
  • Cerebellum
  • Fear
  • Hippocampus
  • Rat

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. / Pletnikov, Mikhail V.; Rubin, Steven A.; Schwartz, Gary J.; Moran, Timothy H.; Sobotka, Thomas J.; Carbone, Kathryn M.

In: Physiology and Behavior, Vol. 66, No. 5, 07.1999, p. 823-831.

Research output: Contribution to journalArticle

Pletnikov, Mikhail V. ; Rubin, Steven A. ; Schwartz, Gary J. ; Moran, Timothy H. ; Sobotka, Thomas J. ; Carbone, Kathryn M. / Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. In: Physiology and Behavior. 1999 ; Vol. 66, No. 5. pp. 823-831.
@article{4f05cd3862144f7f9fbb0f0fcac0f00d,
title = "Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats",
abstract = "Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum. When mature, neonatally BDV-infected rats show extreme locomotor hyperactivity and reduced freezing behavior in novel environments. Traditional interpretation of both of these behavioral abnormalities would suggest decreased anxiety in infected rats compared to normal animals. However, it also possible that the locomotor hyperactivity in infected rats reflects higher rather than reduced anxiety, and is the result of increased escape responses to aversive stimuli. The present experiments were undertaken to test a hypothesis about elevated anxiety in neonatally BDV-infected adult Lewis rats by studying their species-specific fear-related responses. Compared to normal subjects, BDV-infected rats exhibited locomotor hyperactivity and elevated defecation in a highly aversive, brightly lit open field. As expected, in a less aversive, dimly lit open field, uninfected controls increased ambulation, whereas infected rats significantly decreased locomotor activity and defecation. Unlike uninfected rats, BDV-infected rats exhibited an attenuated freezing response immediately after loud auditory stimuli. On the contrary, immediate freezing responses following footshock were comparable in the two groups of animals indicating an intact ability to freeze in BDV-infected rats. Despite a decreased baseline startle responsiveness, BDV-infected rats demonstrated increased sensitization of the startle response by preceding footshocks, suggesting a tendency toward elevated escape responses. Compared to normal subjects, BDV-infected rats showed decreased conditional freezing and elevated conditional defecation response in the context previously paired with aversive stimulation indicating sparing of an autonomic component of fear conditioning. The findings indicate that neonatally BDV-infected adult rats are hyperreactive to aversive stimuli, possibly as a result of chronic emotional abnormalities. Copyright (C) 1999 Elsevier Science Inc.",
keywords = "Anxiety, Borna, Cerebellum, Fear, Hippocampus, Rat",
author = "Pletnikov, {Mikhail V.} and Rubin, {Steven A.} and Schwartz, {Gary J.} and Moran, {Timothy H.} and Sobotka, {Thomas J.} and Carbone, {Kathryn M.}",
year = "1999",
month = "7",
doi = "10.1016/S0031-9384(99)00021-9",
language = "English (US)",
volume = "66",
pages = "823--831",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats

AU - Pletnikov, Mikhail V.

AU - Rubin, Steven A.

AU - Schwartz, Gary J.

AU - Moran, Timothy H.

AU - Sobotka, Thomas J.

AU - Carbone, Kathryn M.

PY - 1999/7

Y1 - 1999/7

N2 - Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum. When mature, neonatally BDV-infected rats show extreme locomotor hyperactivity and reduced freezing behavior in novel environments. Traditional interpretation of both of these behavioral abnormalities would suggest decreased anxiety in infected rats compared to normal animals. However, it also possible that the locomotor hyperactivity in infected rats reflects higher rather than reduced anxiety, and is the result of increased escape responses to aversive stimuli. The present experiments were undertaken to test a hypothesis about elevated anxiety in neonatally BDV-infected adult Lewis rats by studying their species-specific fear-related responses. Compared to normal subjects, BDV-infected rats exhibited locomotor hyperactivity and elevated defecation in a highly aversive, brightly lit open field. As expected, in a less aversive, dimly lit open field, uninfected controls increased ambulation, whereas infected rats significantly decreased locomotor activity and defecation. Unlike uninfected rats, BDV-infected rats exhibited an attenuated freezing response immediately after loud auditory stimuli. On the contrary, immediate freezing responses following footshock were comparable in the two groups of animals indicating an intact ability to freeze in BDV-infected rats. Despite a decreased baseline startle responsiveness, BDV-infected rats demonstrated increased sensitization of the startle response by preceding footshocks, suggesting a tendency toward elevated escape responses. Compared to normal subjects, BDV-infected rats showed decreased conditional freezing and elevated conditional defecation response in the context previously paired with aversive stimulation indicating sparing of an autonomic component of fear conditioning. The findings indicate that neonatally BDV-infected adult rats are hyperreactive to aversive stimuli, possibly as a result of chronic emotional abnormalities. Copyright (C) 1999 Elsevier Science Inc.

AB - Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum. When mature, neonatally BDV-infected rats show extreme locomotor hyperactivity and reduced freezing behavior in novel environments. Traditional interpretation of both of these behavioral abnormalities would suggest decreased anxiety in infected rats compared to normal animals. However, it also possible that the locomotor hyperactivity in infected rats reflects higher rather than reduced anxiety, and is the result of increased escape responses to aversive stimuli. The present experiments were undertaken to test a hypothesis about elevated anxiety in neonatally BDV-infected adult Lewis rats by studying their species-specific fear-related responses. Compared to normal subjects, BDV-infected rats exhibited locomotor hyperactivity and elevated defecation in a highly aversive, brightly lit open field. As expected, in a less aversive, dimly lit open field, uninfected controls increased ambulation, whereas infected rats significantly decreased locomotor activity and defecation. Unlike uninfected rats, BDV-infected rats exhibited an attenuated freezing response immediately after loud auditory stimuli. On the contrary, immediate freezing responses following footshock were comparable in the two groups of animals indicating an intact ability to freeze in BDV-infected rats. Despite a decreased baseline startle responsiveness, BDV-infected rats demonstrated increased sensitization of the startle response by preceding footshocks, suggesting a tendency toward elevated escape responses. Compared to normal subjects, BDV-infected rats showed decreased conditional freezing and elevated conditional defecation response in the context previously paired with aversive stimulation indicating sparing of an autonomic component of fear conditioning. The findings indicate that neonatally BDV-infected adult rats are hyperreactive to aversive stimuli, possibly as a result of chronic emotional abnormalities. Copyright (C) 1999 Elsevier Science Inc.

KW - Anxiety

KW - Borna

KW - Cerebellum

KW - Fear

KW - Hippocampus

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0032974007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032974007&partnerID=8YFLogxK

U2 - 10.1016/S0031-9384(99)00021-9

DO - 10.1016/S0031-9384(99)00021-9

M3 - Article

C2 - 10405111

AN - SCOPUS:0032974007

VL - 66

SP - 823

EP - 831

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -