Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women

Alfonso J. García-Piñeres, Allan Hildesheim, Rolando Herrero, Matthew Trivett, Marcus Williams, Ivannia Atmetlla, Margarita Ramírez, Maricela Villegas, Mark Schiffman, Ana Cecilia Rodríguez, Robert D. Burk, Mariana Hildesheim, Enrique Freer, José Bonilla, Concepción Bratti, Jay A. Berzofsky, Ligia A. Pinto

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Abstract

The development of cervical cancer and its precursors are linked to persistent infection with oncogenic types of human papillomavirus (HPV). Host immune responses seem to be determinants of risk for this disease. However, little is known about the immunologic determinants of HPV persistence. Here, we examined the association between lymphoproliferative responses to antigens/mitogens and persistent HPV infection in women older than 45 years. Women included in this study were participants in a 10,000-woman population-based cohort study of cervical neoplasia in Costa Rica. Women older than 45 years and HPV DNA positive at a screening visit were selected as cases (n = 283). We selected a comparably sized control group of HPV DNA-negative women, matched to cases on age and time since enrollment (n = 261). At an additional clinical visit, women were cytologically and virologically rescreened, and cervical and blood specimens were collected. Proliferative responses to phytohemagglutinin (PHA), influenza virus (Flu), and HPV16 virus-like particle (VLP) were lower among women with persistent HPV infection [median counts per minute (cpm): 72,849 for PHA, 1,241 for Flu, and 727 for VLP] than for the control group (median cpm: 107,049 for PHA, 2,111 for Flu, and 2,068 for VLP). The decreases were most profound in women with long-term persistence and were only observed for the oldest age group (≥65 years). Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect.

Original languageEnglish (US)
Pages (from-to)11070-11076
Number of pages7
JournalCancer Research
Volume66
Issue number22
DOIs
StatePublished - Nov 15 2006

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Papillomavirus Infections
Phytohemagglutinins
Virion
Costa Rica
Control Groups
DNA
Orthomyxoviridae
Mitogens
Uterine Cervical Neoplasms
Cohort Studies
Age Groups
Antigens
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

García-Piñeres, A. J., Hildesheim, A., Herrero, R., Trivett, M., Williams, M., Atmetlla, I., ... Pinto, L. A. (2006). Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Cancer Research, 66(22), 11070-11076. https://doi.org/10.1158/0008-5472.CAN-06-2034

Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. / García-Piñeres, Alfonso J.; Hildesheim, Allan; Herrero, Rolando; Trivett, Matthew; Williams, Marcus; Atmetlla, Ivannia; Ramírez, Margarita; Villegas, Maricela; Schiffman, Mark; Rodríguez, Ana Cecilia; Burk, Robert D.; Hildesheim, Mariana; Freer, Enrique; Bonilla, José; Bratti, Concepción; Berzofsky, Jay A.; Pinto, Ligia A.

In: Cancer Research, Vol. 66, No. 22, 15.11.2006, p. 11070-11076.

Research output: Contribution to journalArticle

García-Piñeres, AJ, Hildesheim, A, Herrero, R, Trivett, M, Williams, M, Atmetlla, I, Ramírez, M, Villegas, M, Schiffman, M, Rodríguez, AC, Burk, RD, Hildesheim, M, Freer, E, Bonilla, J, Bratti, C, Berzofsky, JA & Pinto, LA 2006, 'Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women', Cancer Research, vol. 66, no. 22, pp. 11070-11076. https://doi.org/10.1158/0008-5472.CAN-06-2034
García-Piñeres AJ, Hildesheim A, Herrero R, Trivett M, Williams M, Atmetlla I et al. Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Cancer Research. 2006 Nov 15;66(22):11070-11076. https://doi.org/10.1158/0008-5472.CAN-06-2034
García-Piñeres, Alfonso J. ; Hildesheim, Allan ; Herrero, Rolando ; Trivett, Matthew ; Williams, Marcus ; Atmetlla, Ivannia ; Ramírez, Margarita ; Villegas, Maricela ; Schiffman, Mark ; Rodríguez, Ana Cecilia ; Burk, Robert D. ; Hildesheim, Mariana ; Freer, Enrique ; Bonilla, José ; Bratti, Concepción ; Berzofsky, Jay A. ; Pinto, Ligia A. / Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. In: Cancer Research. 2006 ; Vol. 66, No. 22. pp. 11070-11076.
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AU - Williams, Marcus

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AU - Rodríguez, Ana Cecilia

AU - Burk, Robert D.

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AU - Freer, Enrique

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