Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV

Zainab A. Malik, Susan M. Hailpern, Robert D. Burk

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Whether persistent human papillomavirus (HPV) IgG antibodies following natural infection are protective against subsequent infection is unknown. In a cohort of 508 college women followed for 3y, persistent seropositivity was defined as the presence of type-specific HPV virus-like particle (VLP) antibodies at ≥2 consecutive visits 1y apart. Protection from incident infection with any HPV was conferred by persistent antibodies to HPV16 (p=0.02), HPV31 (p<0.001), HPV33 (p=0.03), HPV35 (p=0.002), HPV52 (p=0.007), HPV45 (p=0.003), and HPV53 (p=0.01). The risk of incident infection with species-specific HPV types was also decreased in women with persistent antibodies to any HPV type in that group, suggesting that exposure to HPV with persistent development of antibody response can be protective, and may explain the decreased efficacy of HPV vaccine in women with prior exposure.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalViral Immunology
Volume22
Issue number6
DOIs
StatePublished - Dec 1 2009

Fingerprint

Papillomaviridae
Virion
Antibodies
Infection
Papillomavirus Vaccines
Antibody Formation
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Molecular Medicine

Cite this

Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV. / Malik, Zainab A.; Hailpern, Susan M.; Burk, Robert D.

In: Viral Immunology, Vol. 22, No. 6, 01.12.2009, p. 445-449.

Research output: Contribution to journalArticle

@article{912afa76f2cd48d7bbeb89c161382185,
title = "Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV",
abstract = "Whether persistent human papillomavirus (HPV) IgG antibodies following natural infection are protective against subsequent infection is unknown. In a cohort of 508 college women followed for 3y, persistent seropositivity was defined as the presence of type-specific HPV virus-like particle (VLP) antibodies at ≥2 consecutive visits 1y apart. Protection from incident infection with any HPV was conferred by persistent antibodies to HPV16 (p=0.02), HPV31 (p<0.001), HPV33 (p=0.03), HPV35 (p=0.002), HPV52 (p=0.007), HPV45 (p=0.003), and HPV53 (p=0.01). The risk of incident infection with species-specific HPV types was also decreased in women with persistent antibodies to any HPV type in that group, suggesting that exposure to HPV with persistent development of antibody response can be protective, and may explain the decreased efficacy of HPV vaccine in women with prior exposure.",
author = "Malik, {Zainab A.} and Hailpern, {Susan M.} and Burk, {Robert D.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1089/vim.2009.0055",
language = "English (US)",
volume = "22",
pages = "445--449",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

TY - JOUR

T1 - Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV

AU - Malik, Zainab A.

AU - Hailpern, Susan M.

AU - Burk, Robert D.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Whether persistent human papillomavirus (HPV) IgG antibodies following natural infection are protective against subsequent infection is unknown. In a cohort of 508 college women followed for 3y, persistent seropositivity was defined as the presence of type-specific HPV virus-like particle (VLP) antibodies at ≥2 consecutive visits 1y apart. Protection from incident infection with any HPV was conferred by persistent antibodies to HPV16 (p=0.02), HPV31 (p<0.001), HPV33 (p=0.03), HPV35 (p=0.002), HPV52 (p=0.007), HPV45 (p=0.003), and HPV53 (p=0.01). The risk of incident infection with species-specific HPV types was also decreased in women with persistent antibodies to any HPV type in that group, suggesting that exposure to HPV with persistent development of antibody response can be protective, and may explain the decreased efficacy of HPV vaccine in women with prior exposure.

AB - Whether persistent human papillomavirus (HPV) IgG antibodies following natural infection are protective against subsequent infection is unknown. In a cohort of 508 college women followed for 3y, persistent seropositivity was defined as the presence of type-specific HPV virus-like particle (VLP) antibodies at ≥2 consecutive visits 1y apart. Protection from incident infection with any HPV was conferred by persistent antibodies to HPV16 (p=0.02), HPV31 (p<0.001), HPV33 (p=0.03), HPV35 (p=0.002), HPV52 (p=0.007), HPV45 (p=0.003), and HPV53 (p=0.01). The risk of incident infection with species-specific HPV types was also decreased in women with persistent antibodies to any HPV type in that group, suggesting that exposure to HPV with persistent development of antibody response can be protective, and may explain the decreased efficacy of HPV vaccine in women with prior exposure.

UR - http://www.scopus.com/inward/record.url?scp=71449126003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71449126003&partnerID=8YFLogxK

U2 - 10.1089/vim.2009.0055

DO - 10.1089/vim.2009.0055

M3 - Article

VL - 22

SP - 445

EP - 449

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 6

ER -