Permission to enter cell by shape: Nanodisk vs Nanosphere

Yi Zhang, Samuel Tekobo, Ying Tu, Qunfang Zhou, Xinlong Jin, Sergey A. Dergunov, Eugene Pinkhassik, Bing Yan

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.

Original languageEnglish (US)
Pages (from-to)4099-4105
Number of pages7
JournalACS Applied Materials and Interfaces
Volume4
Issue number8
DOIs
StatePublished - Aug 22 2012
Externally publishedYes

Fingerprint

Nanospheres
Nanoparticles
Molecular imaging
Polystyrenes
Cell death
Cell membranes
Stem cells
Tissue engineering
Cells
Apoptosis
Imaging techniques

Keywords

  • cell uptake
  • cytotoxicity
  • membrane permeability
  • nanodisk

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Zhang, Y., Tekobo, S., Tu, Y., Zhou, Q., Jin, X., Dergunov, S. A., ... Yan, B. (2012). Permission to enter cell by shape: Nanodisk vs Nanosphere. ACS Applied Materials and Interfaces, 4(8), 4099-4105. https://doi.org/10.1021/am300840p

Permission to enter cell by shape : Nanodisk vs Nanosphere. / Zhang, Yi; Tekobo, Samuel; Tu, Ying; Zhou, Qunfang; Jin, Xinlong; Dergunov, Sergey A.; Pinkhassik, Eugene; Yan, Bing.

In: ACS Applied Materials and Interfaces, Vol. 4, No. 8, 22.08.2012, p. 4099-4105.

Research output: Contribution to journalArticle

Zhang, Y, Tekobo, S, Tu, Y, Zhou, Q, Jin, X, Dergunov, SA, Pinkhassik, E & Yan, B 2012, 'Permission to enter cell by shape: Nanodisk vs Nanosphere', ACS Applied Materials and Interfaces, vol. 4, no. 8, pp. 4099-4105. https://doi.org/10.1021/am300840p
Zhang, Yi ; Tekobo, Samuel ; Tu, Ying ; Zhou, Qunfang ; Jin, Xinlong ; Dergunov, Sergey A. ; Pinkhassik, Eugene ; Yan, Bing. / Permission to enter cell by shape : Nanodisk vs Nanosphere. In: ACS Applied Materials and Interfaces. 2012 ; Vol. 4, No. 8. pp. 4099-4105.
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