Permission to enter cell by shape: Nanodisk vs Nanosphere

Yi Zhang, Samuel Tekobo, Ying Tu, Qunfang Zhou, Xinlong Jin, Sergey A. Dergunov, Eugene Pinkhassik, Bing Yan

Research output: Contribution to journalArticle

80 Scopus citations


Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.

Original languageEnglish (US)
Pages (from-to)4099-4105
Number of pages7
JournalACS Applied Materials and Interfaces
Issue number8
Publication statusPublished - Aug 22 2012
Externally publishedYes



  • cell uptake
  • cytotoxicity
  • membrane permeability
  • nanodisk

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Zhang, Y., Tekobo, S., Tu, Y., Zhou, Q., Jin, X., Dergunov, S. A., ... Yan, B. (2012). Permission to enter cell by shape: Nanodisk vs Nanosphere. ACS Applied Materials and Interfaces, 4(8), 4099-4105.