TY - JOUR
T1 - Peripheral oxidative stress in relapsing-remitting multiple sclerosis
AU - Tasset, Inmaculada
AU - Agüera, Eduardo
AU - Sánchez-López, Fernando
AU - Feijóo, Montserrat
AU - Giraldo, Ana I.
AU - Cruz, Antonio H.
AU - Gascón, Félix
AU - Túnez, Isaac
PY - 2012/4
Y1 - 2012/4
N2 - Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.
AB - Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.
KW - Antioxidant system
KW - Global oxidative stress
KW - Glutathione redox system
KW - Multiple sclerosis
KW - Oxidative stress
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U2 - 10.1016/j.clinbiochem.2012.01.023
DO - 10.1016/j.clinbiochem.2012.01.023
M3 - Article
C2 - 22330938
AN - SCOPUS:84858444025
SN - 0009-9120
VL - 45
SP - 440
EP - 444
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 6
ER -