Peripheral oxidative stress in relapsing-remitting multiple sclerosis

Inmaculada Tasset, Eduardo Agüera, Fernando Sánchez-López, Montserrat Feijóo, Ana I. Giraldo, Antonio H. Cruz, Félix Gascón, Isaac Túnez

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalClinical Biochemistry
Volume45
Issue number6
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Relapsing-Remitting Multiple Sclerosis
Oxidative stress
Glutathione Disulfide
Oxidative Stress
Glutathione
Glutathione Reductase
Glutathione Peroxidase
Glutathione Transferase
Superoxide Dismutase
Blood
Antioxidants
Vascular Cell Adhesion Molecule-1
Serum
Peroxidase
Proteins
Adhesion
Recurrence
Molecules

Keywords

  • Antioxidant system
  • Global oxidative stress
  • Glutathione redox system
  • Multiple sclerosis
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Tasset, I., Agüera, E., Sánchez-López, F., Feijóo, M., Giraldo, A. I., Cruz, A. H., ... Túnez, I. (2012). Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clinical Biochemistry, 45(6), 440-444. https://doi.org/10.1016/j.clinbiochem.2012.01.023

Peripheral oxidative stress in relapsing-remitting multiple sclerosis. / Tasset, Inmaculada; Agüera, Eduardo; Sánchez-López, Fernando; Feijóo, Montserrat; Giraldo, Ana I.; Cruz, Antonio H.; Gascón, Félix; Túnez, Isaac.

In: Clinical Biochemistry, Vol. 45, No. 6, 04.2012, p. 440-444.

Research output: Contribution to journalArticle

Tasset, I, Agüera, E, Sánchez-López, F, Feijóo, M, Giraldo, AI, Cruz, AH, Gascón, F & Túnez, I 2012, 'Peripheral oxidative stress in relapsing-remitting multiple sclerosis', Clinical Biochemistry, vol. 45, no. 6, pp. 440-444. https://doi.org/10.1016/j.clinbiochem.2012.01.023
Tasset I, Agüera E, Sánchez-López F, Feijóo M, Giraldo AI, Cruz AH et al. Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clinical Biochemistry. 2012 Apr;45(6):440-444. https://doi.org/10.1016/j.clinbiochem.2012.01.023
Tasset, Inmaculada ; Agüera, Eduardo ; Sánchez-López, Fernando ; Feijóo, Montserrat ; Giraldo, Ana I. ; Cruz, Antonio H. ; Gascón, Félix ; Túnez, Isaac. / Peripheral oxidative stress in relapsing-remitting multiple sclerosis. In: Clinical Biochemistry. 2012 ; Vol. 45, No. 6. pp. 440-444.
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abstract = "Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.",
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AB - Objectives: To evaluate levels of oxidative stress in blood samples in patients with relapsing-remitting MS (RR-MS). Design and methods: Peripheral blood samples were collected from 24 RR-MS patients and 15 healthy controls. Levels of the following were measured: carbonylated proteins, 8-hydroxy-2'deoxyguanosine (8OHdG), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-S-transferase (GST), myeloperoxidase (MPO), antioxidant gap, total antioxidant capacity (PAO), global oxidative stress (GOS), serum vascular cell adhesion molecule-1 (sVCAM-1) and serum inter-cellular adhesion molecule 1 (sICAM-1). Results: Values for carbonylated proteins, 8OHdG, total glutathione, GSH, GSH/GSSG ratio, SOD, GRd and GOS were significantly higher in RR-MS patients than in healthy controls. By contrast, PAO, GSSG, GPx and GST were lower in RR-MS patients. Conclusion: Oxidative stress plays a major role in MS, and is observed prior to relapse.

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