Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder

Donatella Marazziti, Eric Hollander, Patrizia Lensi, Susanna Ravagli, Giovanni Battista Cassano

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

In an attempt to clarify the possible role of a serotonergic and dopaminergic dysfunction in obsessive-compulsive disorder (OCD), we measured platelet 3H-imipramine (3H-IMI) binding, serotonin uptake, and platelet sulfotransferase activity in 17 drug-free OCD patients and an equal number of healthy controls. Serotonin uptake and 3H-IMI bindings sites in platelets have been shown to constitute peripheral markers of those present in presynaptic serotonergic neurons. Sulfotransferase, an enzyme involved in the catabolism of phenolic compounds and of cathecholamines such as dopamine, has similar kinetic characteristics in brain and platelets. Our results showed a lower number of 3H-IMI binding sites and a higher level of sulfotransferase activity in OCD patients compared with those in controls. These preliminary results suggest involvement of both the serotonin and dopamine systems in OCD.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalPsychiatry Research
Volume42
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Sulfotransferases
Imipramine
Dopamine
Serotonin
Blood Platelets
Binding Sites
Serotonergic Neurons
Brain
Enzymes
Pharmaceutical Preparations

Keywords

  • H-imipramine binding
  • Catecholamines
  • platelets
  • sulfotransferase

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder. / Marazziti, Donatella; Hollander, Eric; Lensi, Patrizia; Ravagli, Susanna; Cassano, Giovanni Battista.

In: Psychiatry Research, Vol. 42, No. 1, 1992, p. 41-51.

Research output: Contribution to journalArticle

Marazziti, Donatella ; Hollander, Eric ; Lensi, Patrizia ; Ravagli, Susanna ; Cassano, Giovanni Battista. / Peripheral markers of serotonin and dopamine function in obsessive-compulsive disorder. In: Psychiatry Research. 1992 ; Vol. 42, No. 1. pp. 41-51.
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