Peripheral Blood Cytokine Profiling During Pregnancy and Post-partum Periods

Thomas A. Kraus, Rhoda S. Sperling, Stephanie M. Engel, Yungtai Lo, Lisa Kellerman, Tricia Singh, Martine Loubeau, Yongchao Ge, Jose L. Garrido, Marta Rodríguez-García, Thomas M. Moran

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Problem Pregnancy requires that the maternal immune system adapt to prevent rejection of the fetal semi-allograft. This immunologic adaptation may contribute to pregnancy-related alterations in disease susceptibility and severity of infections from viral pathogens such as influenza virus.Method of Study As part of a larger study investigating the maternal systemic immune response during pregnancy, peripheral blood was collected three times during pregnancy and twice post-partum to measure serum levels of 23 cytokines, chemokines, and growth factors. This longitudinal study design allowed each woman's post-partum blood draw to serve as her own comparison, thus controlling for interpersonal variability in expression levels.Results When compared to the post-partum samples, significant pregnancy-related changes in IFNγ, TNFα, VEGF, GCSF, Eotaxin, and MCP-1 expression were observed. These changes have significant immunologic effects in vivo and in culture.Conclusion Pregnancy-associated changes to steady state serum cytokines may have important immunologic consequence.

Original languageEnglish (US)
Pages (from-to)411-426
Number of pages16
JournalAmerican Journal of Reproductive Immunology
Volume64
Issue number6
DOIs
StatePublished - Dec 2010
Externally publishedYes

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Cytokines
Pregnancy
Chemokine CCL11
Mothers
Disease Susceptibility
Virus Diseases
Orthomyxoviridae
Serum
Chemokines
Vascular Endothelial Growth Factor A
Allografts
Longitudinal Studies
Immune System
Intercellular Signaling Peptides and Proteins

Keywords

  • Immunity
  • Reproduction
  • Serum
  • Systemic

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Peripheral Blood Cytokine Profiling During Pregnancy and Post-partum Periods. / Kraus, Thomas A.; Sperling, Rhoda S.; Engel, Stephanie M.; Lo, Yungtai; Kellerman, Lisa; Singh, Tricia; Loubeau, Martine; Ge, Yongchao; Garrido, Jose L.; Rodríguez-García, Marta; Moran, Thomas M.

In: American Journal of Reproductive Immunology, Vol. 64, No. 6, 12.2010, p. 411-426.

Research output: Contribution to journalArticle

Kraus, TA, Sperling, RS, Engel, SM, Lo, Y, Kellerman, L, Singh, T, Loubeau, M, Ge, Y, Garrido, JL, Rodríguez-García, M & Moran, TM 2010, 'Peripheral Blood Cytokine Profiling During Pregnancy and Post-partum Periods', American Journal of Reproductive Immunology, vol. 64, no. 6, pp. 411-426. https://doi.org/10.1111/j.1600-0897.2010.00889.x
Kraus, Thomas A. ; Sperling, Rhoda S. ; Engel, Stephanie M. ; Lo, Yungtai ; Kellerman, Lisa ; Singh, Tricia ; Loubeau, Martine ; Ge, Yongchao ; Garrido, Jose L. ; Rodríguez-García, Marta ; Moran, Thomas M. / Peripheral Blood Cytokine Profiling During Pregnancy and Post-partum Periods. In: American Journal of Reproductive Immunology. 2010 ; Vol. 64, No. 6. pp. 411-426.
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