TY - JOUR
T1 - Peripheral Blood Cytokine Profiling During Pregnancy and Post-partum Periods
AU - Kraus, Thomas A.
AU - Sperling, Rhoda S.
AU - Engel, Stephanie M.
AU - Lo, Yungtai
AU - Kellerman, Lisa
AU - Singh, Tricia
AU - Loubeau, Martine
AU - Ge, Yongchao
AU - Garrido, Jose L.
AU - Rodríguez-García, Marta
AU - Moran, Thomas M.
PY - 2010/12
Y1 - 2010/12
N2 - Problem Pregnancy requires that the maternal immune system adapt to prevent rejection of the fetal semi-allograft. This immunologic adaptation may contribute to pregnancy-related alterations in disease susceptibility and severity of infections from viral pathogens such as influenza virus.Method of Study As part of a larger study investigating the maternal systemic immune response during pregnancy, peripheral blood was collected three times during pregnancy and twice post-partum to measure serum levels of 23 cytokines, chemokines, and growth factors. This longitudinal study design allowed each woman's post-partum blood draw to serve as her own comparison, thus controlling for interpersonal variability in expression levels.Results When compared to the post-partum samples, significant pregnancy-related changes in IFNγ, TNFα, VEGF, GCSF, Eotaxin, and MCP-1 expression were observed. These changes have significant immunologic effects in vivo and in culture.Conclusion Pregnancy-associated changes to steady state serum cytokines may have important immunologic consequence.
AB - Problem Pregnancy requires that the maternal immune system adapt to prevent rejection of the fetal semi-allograft. This immunologic adaptation may contribute to pregnancy-related alterations in disease susceptibility and severity of infections from viral pathogens such as influenza virus.Method of Study As part of a larger study investigating the maternal systemic immune response during pregnancy, peripheral blood was collected three times during pregnancy and twice post-partum to measure serum levels of 23 cytokines, chemokines, and growth factors. This longitudinal study design allowed each woman's post-partum blood draw to serve as her own comparison, thus controlling for interpersonal variability in expression levels.Results When compared to the post-partum samples, significant pregnancy-related changes in IFNγ, TNFα, VEGF, GCSF, Eotaxin, and MCP-1 expression were observed. These changes have significant immunologic effects in vivo and in culture.Conclusion Pregnancy-associated changes to steady state serum cytokines may have important immunologic consequence.
KW - Immunity
KW - Reproduction
KW - Serum
KW - Systemic
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U2 - 10.1111/j.1600-0897.2010.00889.x
DO - 10.1111/j.1600-0897.2010.00889.x
M3 - Article
C2 - 20712812
AN - SCOPUS:77958536100
SN - 1046-7408
VL - 64
SP - 411
EP - 426
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 6
ER -