Peripheral arterial disease in HIV-infected and uninfected women

A. Sharma, S. Holman, R. Pitts, H. L. Minkoff, J. A. Dehovitz, J. Lazar

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: Although HIV infection has been associated with increased risk of subclinical atherosclerosis and cardiovascular events, peripheral arterial disease (PAD) has not been assessed in HIV-infected patients. The objective of this study was to determine the prevalence of, and risk factors for, PAD using ankle-brachial index (ABI) measurement in HIV-infected and uninfected women. Methods: ABI was determined for 335 participants in the Women's Interagency HIV Study (WIHS). A cross-sectional analysis was conducted to determine factors associated with high (≥1.40) ABI. Results: The prevalence of low ABI (≤0.9) was 0.9% (n = 3) and the prevalence of high ABI (≥1.40) was 6.9% (n = 23). The prevalence of low ABI was too low to allow risk factor analysis. On multivariate analysis, factors associated with high ABI were current cigarette smoking [adjusted odds ratio (OR adj) 2.53, 95% confidence interval (CI) 0.99-6.43], being underweight (OR adj 11.0, 95% CI 1.61-75.63) and being overweight (OR adj 5.40, 95% CI 1.13-25.89). Conclusions: Although the prevalence of ABI ≤0.9 was low in this cohort of HIV-infected and uninfected women, the prevalence of ABI ≥1.40 was unexpectedly high. Further studies are indicated to determine the clinical significance of high ABI and its relation to the risk of cardiovascular events in HIV-infected women.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalHIV Medicine
Issue number8
StatePublished - Nov 2007
Externally publishedYes


  • Ankle-brachial index
  • HIV
  • Peripheral arterial disease
  • Women

ASJC Scopus subject areas

  • Health Policy
  • Infectious Diseases
  • Pharmacology (medical)


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