Perioperative Outcomes after Lung Resection in Obese Patients

Subroto Paul, Weston Andrews, Nonso C. Osakwe, Jeffrey L. Port, Paul C. Lee, Brendon M. Stiles, Nasser K. Altorki

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background Obesity is a growing epidemic in the developed world. However, little is known about the impact of obesity on the perioperative morbidity and mortality after lung resection. Patients and Methods We analyzed the American College of Surgeons National Surgical Quality Improvement Program database from 2005 to 2010 to determine whether obesity is a risk factor for perioperative morbidity and mortality after pulmonary resection. Demographic, clinical, intraoperative, and morbidity and mortality data were collected. Multivariable predictors of morbidity and mortality were determined using regression analysis. Results A total of 5,216 lung resections were identified (1,372 wedges, 3,713 lobectomies, and 131 pneumonectomies). The median age was 66 years and 2,587 (49.6%) were females. The body mass index (BMI, kg/m2) of the patients was as follows: 192 (3.7%)<18.5; 1,727 (33.1%) 18.5 to 24.9; 1,754 (33.6%) 25 to 29.9; and 1,488 (28.5%)>30. In-hospital mortality and all-cause morbidity was 2.4% (n=127) and 14.5% (n=757) for the entire cohort of patients, respectively. BMI was not found to be a predictor of increased mortality or morbidity, even in the morbidly obese (BMI>35). Rather, age, approach (video-assisted thoracoscopic surgery vs. open), parameters assessing performance status, operative time, and preoperative radiation therapy were the predictors of morbidity and mortality. Conversely, being overweight (BMI 25-30) approached significance as a multivariate predictor for decreased pulmonary complications (odds ratio, 0.77 [0.592-1.004]; p=0.054) consistent with the obesity paradox observed after nonbariatric general surgery. Conclusion Our large national study shows that obesity does not negatively impact perioperative mortality and morbidity in patients undergoing lung resection. Surgical resections should not be denied to obese (BMI>30) patients.

Original languageEnglish (US)
Pages (from-to)544-550
Number of pages7
JournalThoracic and Cardiovascular Surgeon
Volume63
Issue number7
DOIs
StatePublished - Jul 28 2014
Externally publishedYes

Keywords

  • BMI
  • lung resection
  • obese
  • perioperative outcomes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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