Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients

Yunfang Joan Hou; Daniel C. Lee; Wilson Ko; Amie Kim; Jeanie Lee; Ketan Shevde; Ming Zhang

doi:10.1016/j.athoracsur.2010.04.003

Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients

Yunfang Joan Hou, Daniel C. Lee, Wilson Ko, Amie Kim, Jeanie Lee, Ketan Shevde, Ming Zhang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery. Analysis of their blood samples from the perioperative period showed their MBL levels were abruptly increased at 24 hours after surgery. However, 2 patients had a subsequent drop of MBL at 48 hours, and both expired. These data indicated that the postoperative decrease of MBL may have been related with an unfavorable outcome after cardiac surgery.

Original language	English (US)
Pages (from-to)	1357-1358
Number of pages	2
Journal	Annals of Thoracic Surgery
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.athoracsur.2010.04.003
State	Published - Oct 2010
Externally published	Yes

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.athoracsur.2010.04.003

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@article{66e030c8c40c4d3195b88d6931512c06,

title = "Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients",

abstract = "Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery. Analysis of their blood samples from the perioperative period showed their MBL levels were abruptly increased at 24 hours after surgery. However, 2 patients had a subsequent drop of MBL at 48 hours, and both expired. These data indicated that the postoperative decrease of MBL may have been related with an unfavorable outcome after cardiac surgery.",

author = "Hou, {Yunfang Joan} and Lee, {Daniel C.} and Wilson Ko and Amie Kim and Jeanie Lee and Ketan Shevde and Ming Zhang",

note = "Funding Information: The authors would like to thank Dr James Cottrell for his continued support through Brooklyn Anesthesia Research, Inc, and Lawrence Lai, Michael Lee, Amy Gleed, Hsiao-ying Chin, Donna Newman, Chris Johnson, and Downstate CT-ICU staffs for their valuable assistance. The research was funded in part by the National Institutes of Health , Grant No. 1R21HL088527 (MZ) and the Empire Clinical Research Investigator Program (ECRIP) Award of New York State Department of Health (KS and MZ). Yunfang Joan Hou is an ECRIP fellow.",

year = "2010",

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doi = "10.1016/j.athoracsur.2010.04.003",

language = "English (US)",

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AU - Lee, Daniel C.

AU - Ko, Wilson

AU - Kim, Amie

AU - Lee, Jeanie

AU - Shevde, Ketan

AU - Zhang, Ming

N1 - Funding Information: The authors would like to thank Dr James Cottrell for his continued support through Brooklyn Anesthesia Research, Inc, and Lawrence Lai, Michael Lee, Amy Gleed, Hsiao-ying Chin, Donna Newman, Chris Johnson, and Downstate CT-ICU staffs for their valuable assistance. The research was funded in part by the National Institutes of Health , Grant No. 1R21HL088527 (MZ) and the Empire Clinical Research Investigator Program (ECRIP) Award of New York State Department of Health (KS and MZ). Yunfang Joan Hou is an ECRIP fellow.

PY - 2010/10

Y1 - 2010/10

N2 - Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery. Analysis of their blood samples from the perioperative period showed their MBL levels were abruptly increased at 24 hours after surgery. However, 2 patients had a subsequent drop of MBL at 48 hours, and both expired. These data indicated that the postoperative decrease of MBL may have been related with an unfavorable outcome after cardiac surgery.

AB - Previously we reported a case of abrupt change of postoperative mannan-binding-lectin (MBL) in a patient with preexisting MBL deficiency who expired shortly after cardiac surgery. Herein we report additional cases of 3 more patients with preexisting MBL deficiency who underwent cardiac surgery. Analysis of their blood samples from the perioperative period showed their MBL levels were abruptly increased at 24 hours after surgery. However, 2 patients had a subsequent drop of MBL at 48 hours, and both expired. These data indicated that the postoperative decrease of MBL may have been related with an unfavorable outcome after cardiac surgery.

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JF - Annals of Thoracic Surgery

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ER -

Perioperative mannan-binding lectin (MBL) patterns in cardiac surgery may correlate with the clinical outcomes in MBL deficient patients

Abstract

ASJC Scopus subject areas

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