Perioperative effects and safety of nesiritide following cardiac surgery in children

Janet M. Simsic, Mark Scheurer, Joseph D. Tobias, John Berkenbosch, William Schechter, Freddie Madera, Samuel Weinstein, Robert E. Michler

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Nesiritide (Natrecor, Scios Inc), human B-type natriuretic peptide, has hemodynamic effects that may be beneficial in pediatric patients after cardiac surgery. Experience with nesiritide and pediatrics is limited. The purpose of this study was to evaluate perioperative effects and safety of nesiritide in pediatric cardiothoracic surgery. Seventeen patients with congenital heart disease undergoing cardiac surgery were given a loading dose (1 μg/kg) while on cardiopulmonary bypass (constant flow) followed by continuous infusion for 24 hours (0.01 μg/kg/min x 6 hours, then 0.02 μg/kg/min x 18 hours). A 7% decrease in mean blood pressure was seen following nesiritide loading dose on cardiopulmonary bypass. No patient required intervention for hypotension while receiving nesiritide load or infusion. Nesiritide load during surgery and continuous infusion after cardiac surgery in pediatric patients resulted in no significant hemodynamic compromise.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalJournal of Intensive Care Medicine
Volume21
Issue number1
DOIs
StatePublished - Jan 2006

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Brain Natriuretic Peptide
Thoracic Surgery
Safety
Pediatrics
Cardiopulmonary Bypass
Hemodynamics
Hypotension
Heart Diseases
Blood Pressure

Keywords

  • B-type natriuretic peptide
  • Cardiac surgery
  • Congenital heart disease
  • Pediatrics

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Perioperative effects and safety of nesiritide following cardiac surgery in children. / Simsic, Janet M.; Scheurer, Mark; Tobias, Joseph D.; Berkenbosch, John; Schechter, William; Madera, Freddie; Weinstein, Samuel; Michler, Robert E.

In: Journal of Intensive Care Medicine, Vol. 21, No. 1, 01.2006, p. 22-26.

Research output: Contribution to journalArticle

Simsic, Janet M. ; Scheurer, Mark ; Tobias, Joseph D. ; Berkenbosch, John ; Schechter, William ; Madera, Freddie ; Weinstein, Samuel ; Michler, Robert E. / Perioperative effects and safety of nesiritide following cardiac surgery in children. In: Journal of Intensive Care Medicine. 2006 ; Vol. 21, No. 1. pp. 22-26.
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