Periodontal diseases and risk of oral cancer in Southern India

Results from the HeNCe Life study

Claudie Laprise, Hameed Puthiyannal Shahul, Sreenath Arekunnath Madathil, Akhil Soman Thekkepurakkal, Geneviève Castonguay, Ipe Varghese, Shameena Shiraz, Paul Allison, Nicolas F. Schlecht, Marie Claude Rousseau, Eduardo L. Franco, Belinda Nicolau

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Some studies suggest that periodontal diseases increase the risk of oral cancer, but contradictory results also exist. Inadequate control of confounders, including life course exposures, may have influenced prior findings. We estimate the extent to which high levels of periodontal diseases, measured by gingival inflammation and recession, are associated with oral cancer risk using a comprehensive subset of potential confounders and applying a stringent adjustment approach. In a hospital-based case-control study, incident oral cancer cases (N = 350) were recruited from two major referral hospitals in Kerala, South India, from 2008 to 2012. Controls (N = 371), frequency-matched by age and sex, were recruited from clinics at the same hospitals. Structured interviews collected information on several domains of exposure via a detailed life course questionnaire. Periodontal diseases, as measured by gingival inflammation and gingival recession, were evaluated visually by qualified dentists following a detailed protocol. The relationship between periodontal diseases and oral cancer risk was assessed by unconditional logistic regression using a stringent empirical selection of potential confounders corresponding to a 1% change-in-estimates. Generalized gingival recession was significantly associated with oral cancer risk (Odds Ratio = 1.83, 95% Confidence Interval: 1.10–3.04). No significant association was observed between gingival inflammation and oral cancer. Our findings support the hypothesis that high levels of periodontal diseases increase the risk of oral cancer.

Original languageEnglish (US)
Pages (from-to)1512-1519
Number of pages8
JournalInternational Journal of Cancer
Volume139
Issue number7
DOIs
StatePublished - Oct 1 2016

Fingerprint

Mouth Neoplasms
Periodontal Diseases
India
Gingival Recession
Inflammation
Odds Ratio
Dentists
Case-Control Studies
Referral and Consultation
Logistic Models
Confidence Intervals
Interviews

Keywords

  • case-control study
  • gingivitis
  • India
  • mouth neoplasms
  • oral cancer
  • oral health
  • periodontal diseases
  • periodontitis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Laprise, C., Shahul, H. P., Madathil, S. A., Thekkepurakkal, A. S., Castonguay, G., Varghese, I., ... Nicolau, B. (2016). Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. International Journal of Cancer, 139(7), 1512-1519. https://doi.org/10.1002/ijc.30201

Periodontal diseases and risk of oral cancer in Southern India : Results from the HeNCe Life study. / Laprise, Claudie; Shahul, Hameed Puthiyannal; Madathil, Sreenath Arekunnath; Thekkepurakkal, Akhil Soman; Castonguay, Geneviève; Varghese, Ipe; Shiraz, Shameena; Allison, Paul; Schlecht, Nicolas F.; Rousseau, Marie Claude; Franco, Eduardo L.; Nicolau, Belinda.

In: International Journal of Cancer, Vol. 139, No. 7, 01.10.2016, p. 1512-1519.

Research output: Contribution to journalArticle

Laprise, C, Shahul, HP, Madathil, SA, Thekkepurakkal, AS, Castonguay, G, Varghese, I, Shiraz, S, Allison, P, Schlecht, NF, Rousseau, MC, Franco, EL & Nicolau, B 2016, 'Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study', International Journal of Cancer, vol. 139, no. 7, pp. 1512-1519. https://doi.org/10.1002/ijc.30201
Laprise C, Shahul HP, Madathil SA, Thekkepurakkal AS, Castonguay G, Varghese I et al. Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. International Journal of Cancer. 2016 Oct 1;139(7):1512-1519. https://doi.org/10.1002/ijc.30201
Laprise, Claudie ; Shahul, Hameed Puthiyannal ; Madathil, Sreenath Arekunnath ; Thekkepurakkal, Akhil Soman ; Castonguay, Geneviève ; Varghese, Ipe ; Shiraz, Shameena ; Allison, Paul ; Schlecht, Nicolas F. ; Rousseau, Marie Claude ; Franco, Eduardo L. ; Nicolau, Belinda. / Periodontal diseases and risk of oral cancer in Southern India : Results from the HeNCe Life study. In: International Journal of Cancer. 2016 ; Vol. 139, No. 7. pp. 1512-1519.
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