Periodic limb movements and disrupted sleep in children with sickle cell disease

Valerie E. Rogers, Carole L. Marcus, Abbas F. Jawad, Kim Smith-Whitley, Kwaku Ohene-Frempong, Cheryl Bowdre, Julian Allen, Raanan Arens, Thornton B A Mason

Research output: Contribution to journalArticle

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Abstract

Study Objectives: To describe the rate, distribution and correlates of periodic limb movements in sleep (PLMS) in children with sickle cell disease (SCD). Design: Prospective, cross-sectional. Setting: Hospital-based sleep laboratory. Participants: Sixty-four children aged 2-18 years with SCD, hemoglobin SS-type who had an overnight polysomnogram and a parent-completed Pediatric Sleep Questionnaire. Mean age was 8.4 years (SD 4.8); 50% were male. Interventions: N/A Measurements and Results: The mean PLMS index was 3.7 (6.6) and ranged from 0 to 31.8, with 23.4% of the sample having PLMS ≥ 5/h. Sleep efficiency was decreased (P = 0.03), and the total arousal index (P = 0.003) and PLMS arousal index (P < 0.001) were increased in children with PLMS ≥ 5/h compared to those with PLMS < 5/h. PLMS were most frequent in NREM stage 2 sleep and during the fourth hour of sleep. Intermovement interval duration peaked at 25-30 s. "Growing pains worst in bed" or "restlessness of the legs," suggesting restless legs syndrome (RLS), were reported in 12.5% of the total sample and were more common in children with elevated PLMS. A PLMS score for identifying elevated PLMS in children, based on items from the Pediatric Sleep Questionnaire, did not significantly predict PLMS ≥ 5/h. Conclusions: Elevated PLMS are common in children with SCD and are associated with sleep disruption and symptoms of RLS. Future research into the time structure of PLMS, their causes and consequences, and development of a disease-specific sleep disorders screening questionnaire, is needed in children with SCD.

Original languageEnglish (US)
Pages (from-to)899-908
Number of pages10
JournalSleep
Volume34
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

Sickle Cell Anemia
Sleep
Extremities
Restless Legs Syndrome
Arousal
Pediatrics
Sickle Hemoglobin
Psychomotor Agitation
Sleep Stages

Keywords

  • Adolescent
  • Anemia
  • Child
  • Inter-movement interval
  • Periodic limb movements in sleep
  • Sickle cell
  • Sleep disorders
  • Sleep stages

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Rogers, V. E., Marcus, C. L., Jawad, A. F., Smith-Whitley, K., Ohene-Frempong, K., Bowdre, C., ... Mason, T. B. A. (2011). Periodic limb movements and disrupted sleep in children with sickle cell disease. Sleep, 34(7), 899-908. https://doi.org/10.5665/SLEEP.1124

Periodic limb movements and disrupted sleep in children with sickle cell disease. / Rogers, Valerie E.; Marcus, Carole L.; Jawad, Abbas F.; Smith-Whitley, Kim; Ohene-Frempong, Kwaku; Bowdre, Cheryl; Allen, Julian; Arens, Raanan; Mason, Thornton B A.

In: Sleep, Vol. 34, No. 7, 01.07.2011, p. 899-908.

Research output: Contribution to journalArticle

Rogers, VE, Marcus, CL, Jawad, AF, Smith-Whitley, K, Ohene-Frempong, K, Bowdre, C, Allen, J, Arens, R & Mason, TBA 2011, 'Periodic limb movements and disrupted sleep in children with sickle cell disease', Sleep, vol. 34, no. 7, pp. 899-908. https://doi.org/10.5665/SLEEP.1124
Rogers VE, Marcus CL, Jawad AF, Smith-Whitley K, Ohene-Frempong K, Bowdre C et al. Periodic limb movements and disrupted sleep in children with sickle cell disease. Sleep. 2011 Jul 1;34(7):899-908. https://doi.org/10.5665/SLEEP.1124
Rogers, Valerie E. ; Marcus, Carole L. ; Jawad, Abbas F. ; Smith-Whitley, Kim ; Ohene-Frempong, Kwaku ; Bowdre, Cheryl ; Allen, Julian ; Arens, Raanan ; Mason, Thornton B A. / Periodic limb movements and disrupted sleep in children with sickle cell disease. In: Sleep. 2011 ; Vol. 34, No. 7. pp. 899-908.
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abstract = "Study Objectives: To describe the rate, distribution and correlates of periodic limb movements in sleep (PLMS) in children with sickle cell disease (SCD). Design: Prospective, cross-sectional. Setting: Hospital-based sleep laboratory. Participants: Sixty-four children aged 2-18 years with SCD, hemoglobin SS-type who had an overnight polysomnogram and a parent-completed Pediatric Sleep Questionnaire. Mean age was 8.4 years (SD 4.8); 50{\%} were male. Interventions: N/A Measurements and Results: The mean PLMS index was 3.7 (6.6) and ranged from 0 to 31.8, with 23.4{\%} of the sample having PLMS ≥ 5/h. Sleep efficiency was decreased (P = 0.03), and the total arousal index (P = 0.003) and PLMS arousal index (P < 0.001) were increased in children with PLMS ≥ 5/h compared to those with PLMS < 5/h. PLMS were most frequent in NREM stage 2 sleep and during the fourth hour of sleep. Intermovement interval duration peaked at 25-30 s. {"}Growing pains worst in bed{"} or {"}restlessness of the legs,{"} suggesting restless legs syndrome (RLS), were reported in 12.5{\%} of the total sample and were more common in children with elevated PLMS. A PLMS score for identifying elevated PLMS in children, based on items from the Pediatric Sleep Questionnaire, did not significantly predict PLMS ≥ 5/h. Conclusions: Elevated PLMS are common in children with SCD and are associated with sleep disruption and symptoms of RLS. Future research into the time structure of PLMS, their causes and consequences, and development of a disease-specific sleep disorders screening questionnaire, is needed in children with SCD.",
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AU - Ohene-Frempong, Kwaku

AU - Bowdre, Cheryl

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N2 - Study Objectives: To describe the rate, distribution and correlates of periodic limb movements in sleep (PLMS) in children with sickle cell disease (SCD). Design: Prospective, cross-sectional. Setting: Hospital-based sleep laboratory. Participants: Sixty-four children aged 2-18 years with SCD, hemoglobin SS-type who had an overnight polysomnogram and a parent-completed Pediatric Sleep Questionnaire. Mean age was 8.4 years (SD 4.8); 50% were male. Interventions: N/A Measurements and Results: The mean PLMS index was 3.7 (6.6) and ranged from 0 to 31.8, with 23.4% of the sample having PLMS ≥ 5/h. Sleep efficiency was decreased (P = 0.03), and the total arousal index (P = 0.003) and PLMS arousal index (P < 0.001) were increased in children with PLMS ≥ 5/h compared to those with PLMS < 5/h. PLMS were most frequent in NREM stage 2 sleep and during the fourth hour of sleep. Intermovement interval duration peaked at 25-30 s. "Growing pains worst in bed" or "restlessness of the legs," suggesting restless legs syndrome (RLS), were reported in 12.5% of the total sample and were more common in children with elevated PLMS. A PLMS score for identifying elevated PLMS in children, based on items from the Pediatric Sleep Questionnaire, did not significantly predict PLMS ≥ 5/h. Conclusions: Elevated PLMS are common in children with SCD and are associated with sleep disruption and symptoms of RLS. Future research into the time structure of PLMS, their causes and consequences, and development of a disease-specific sleep disorders screening questionnaire, is needed in children with SCD.

AB - Study Objectives: To describe the rate, distribution and correlates of periodic limb movements in sleep (PLMS) in children with sickle cell disease (SCD). Design: Prospective, cross-sectional. Setting: Hospital-based sleep laboratory. Participants: Sixty-four children aged 2-18 years with SCD, hemoglobin SS-type who had an overnight polysomnogram and a parent-completed Pediatric Sleep Questionnaire. Mean age was 8.4 years (SD 4.8); 50% were male. Interventions: N/A Measurements and Results: The mean PLMS index was 3.7 (6.6) and ranged from 0 to 31.8, with 23.4% of the sample having PLMS ≥ 5/h. Sleep efficiency was decreased (P = 0.03), and the total arousal index (P = 0.003) and PLMS arousal index (P < 0.001) were increased in children with PLMS ≥ 5/h compared to those with PLMS < 5/h. PLMS were most frequent in NREM stage 2 sleep and during the fourth hour of sleep. Intermovement interval duration peaked at 25-30 s. "Growing pains worst in bed" or "restlessness of the legs," suggesting restless legs syndrome (RLS), were reported in 12.5% of the total sample and were more common in children with elevated PLMS. A PLMS score for identifying elevated PLMS in children, based on items from the Pediatric Sleep Questionnaire, did not significantly predict PLMS ≥ 5/h. Conclusions: Elevated PLMS are common in children with SCD and are associated with sleep disruption and symptoms of RLS. Future research into the time structure of PLMS, their causes and consequences, and development of a disease-specific sleep disorders screening questionnaire, is needed in children with SCD.

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