Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats

B. Meierfrankenfeld, M. Abelenda, H. Jauker, M. Klingenspor, E. E. Kershaw, Streamson C. Chua, Jr., R. L. Leibel, I. Schmidt

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To find out whether perinatal differences in energy stores are essential for the phenotypic manifestation of the fa/fa genotype in 16-day-old rats, we investigated Zucker rats (13M) x Brown Norway (BN) hybrids. +/fa and fa/fa hybrids were identified by molecular polymorphisms ~1 cM from the fa locus. The fat content of all pups increased rapidly after birth, and differences between +/fa and fa/fa hybrid pups were significant in 7- and 16-day-old rats but not at 0, 1, and 4 days of age. For 16-day-old 13MBN hybrids as well as 13M Zucker rats, plots of carcass fat vs. body mass were closely fitted by parallel regression lines, with carcass fat similarily higher in fa/fa than +/fa pups of both strains. Fetal and neonatal plasma insulin concentration and hepatic glycogen in the 13MBN hybrid pups did not differ between +/fa and fa/fa littermates, nor did the hepatic and adipose tissue triglycerides in 24-h-old 13MBN hybrid pups. The manifest differences between fatty and lean 16-day-old pups thus do not depend on differences in perinatal energy stores.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume270
Issue number4 33-4
StatePublished - 1996
Externally publishedYes

Fingerprint

Rats
Fats
Zucker Rats
Liver Glycogen
Polymorphism
Triglycerides
Insulin
Norway
Tissue
Plasmas
Adipose Tissue
Genotype
Parturition
Liver

Keywords

  • adipose tissue
  • body composition
  • glycogen
  • insulin
  • newborn
  • Zucker rat x Brown Norway hybrids

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry
  • Physiology (medical)

Cite this

Meierfrankenfeld, B., Abelenda, M., Jauker, H., Klingenspor, M., Kershaw, E. E., Chua, Jr., S. C., ... Schmidt, I. (1996). Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. American Journal of Physiology - Endocrinology and Metabolism, 270(4 33-4).

Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. / Meierfrankenfeld, B.; Abelenda, M.; Jauker, H.; Klingenspor, M.; Kershaw, E. E.; Chua, Jr., Streamson C.; Leibel, R. L.; Schmidt, I.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 270, No. 4 33-4, 1996.

Research output: Contribution to journalArticle

Meierfrankenfeld, B, Abelenda, M, Jauker, H, Klingenspor, M, Kershaw, EE, Chua, Jr., SC, Leibel, RL & Schmidt, I 1996, 'Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats', American Journal of Physiology - Endocrinology and Metabolism, vol. 270, no. 4 33-4.
Meierfrankenfeld, B. ; Abelenda, M. ; Jauker, H. ; Klingenspor, M. ; Kershaw, E. E. ; Chua, Jr., Streamson C. ; Leibel, R. L. ; Schmidt, I. / Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. In: American Journal of Physiology - Endocrinology and Metabolism. 1996 ; Vol. 270, No. 4 33-4.
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