Percutaneous treatment of non-paroxysmal atrial fibrillation: A paradigm shift from pulmonary vein to non-pulmonary vein trigger ablation?

Domenico G. Della Rocca, Sanghamitra Mohanty, Chintan Trivedi, Luigi Di Biase, Andrea Natale

Research output: Contribution to journalReview article

6 Scopus citations


Pulmonary vein antrum isolation is the most effective rhythm control strategy in patients with paroxysmal AF. However, catheter ablation of non-paroxysmal AF has a lower success rate, even when persistent isolation of pulmonary veins (PVs) is achieved. As a result of arrhythmia-related electophysiological and structural changes in the atria, sites other than the PVs can harbour triggers. These non-PV triggers contribute to AF relapse. In this article, we summarise the rationale and current evidence supporting the arrhythmogenic role of non-PV triggers and our ablation approach to patients with non-paroxysmal AF.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalArrhythmia and Electrophysiology Review
Issue number4
StatePublished - Dec 1 2018



  • Atrial fibrillation
  • Catheter ablation
  • Non-pulmonary vein trigger
  • Outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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