Penetration of imipenem into human aqueous and vitreous humor

Judith L. Axelrod, James C. Newton, Richard M. Klein, Robert L. Bergen, Mohammed Z. Sheikh

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 μg/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 μg/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.

Original languageEnglish (US)
Pages (from-to)649-653
Number of pages5
JournalAmerican journal of ophthalmology
Volume104
Issue number6
DOIs
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Ophthalmology

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    Axelrod, J. L., Newton, J. C., Klein, R. M., Bergen, R. L., & Sheikh, M. Z. (1987). Penetration of imipenem into human aqueous and vitreous humor. American journal of ophthalmology, 104(6), 649-653. https://doi.org/10.1016/0002-9394(87)90180-2