Penetration of imipenem into human aqueous and vitreous humor

Judith L. Axelrod, James C. Newton, Richard M. Klein, Robert L. Bergen, Mohammed Z. Sheikh

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 μg/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 μg/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.

Original languageEnglish (US)
Pages (from-to)649-653
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume104
Issue number6
StatePublished - 1987
Externally publishedYes

Fingerprint

Vitreous Body
Imipenem
Aqueous Humor
Endophthalmitis
Staphylococcus epidermidis
Vitrectomy
Microbial Sensitivity Tests
Enterobacteriaceae
Cataract
Agar
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Axelrod, J. L., Newton, J. C., Klein, R. M., Bergen, R. L., & Sheikh, M. Z. (1987). Penetration of imipenem into human aqueous and vitreous humor. American Journal of Ophthalmology, 104(6), 649-653.

Penetration of imipenem into human aqueous and vitreous humor. / Axelrod, Judith L.; Newton, James C.; Klein, Richard M.; Bergen, Robert L.; Sheikh, Mohammed Z.

In: American Journal of Ophthalmology, Vol. 104, No. 6, 1987, p. 649-653.

Research output: Contribution to journalArticle

Axelrod, JL, Newton, JC, Klein, RM, Bergen, RL & Sheikh, MZ 1987, 'Penetration of imipenem into human aqueous and vitreous humor', American Journal of Ophthalmology, vol. 104, no. 6, pp. 649-653.
Axelrod JL, Newton JC, Klein RM, Bergen RL, Sheikh MZ. Penetration of imipenem into human aqueous and vitreous humor. American Journal of Ophthalmology. 1987;104(6):649-653.
Axelrod, Judith L. ; Newton, James C. ; Klein, Richard M. ; Bergen, Robert L. ; Sheikh, Mohammed Z. / Penetration of imipenem into human aqueous and vitreous humor. In: American Journal of Ophthalmology. 1987 ; Vol. 104, No. 6. pp. 649-653.
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