Penetration of imipenem into human aqueous and vitreous humor

Judith L. Axelrod; James C. Newton; Richard M. Klein; Robert L. Bergen; Mohammed Z. Sheikh

doi:10.1016/0002-9394(87)90180-2

Penetration of imipenem into human aqueous and vitreous humor

Judith L. Axelrod, James C. Newton, Richard M. Klein, Robert L. Bergen, Mohammed Z. Sheikh

Ophthalmology & Visual Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 μg/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 μg/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC₉₀) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.

Original language	English (US)
Pages (from-to)	649-653
Number of pages	5
Journal	American journal of ophthalmology
Volume	104
Issue number	6
DOIs	https://doi.org/10.1016/0002-9394(87)90180-2
State	Published - Dec 1987

ASJC Scopus subject areas

Ophthalmology

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10.1016/0002-9394(87)90180-2

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@article{2f077c1557074e03953fe286e80e80e3,

title = "Penetration of imipenem into human aqueous and vitreous humor",

abstract = "Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 μg/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 μg/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.",

author = "Axelrod, {Judith L.} and Newton, {James C.} and Klein, {Richard M.} and Bergen, {Robert L.} and Sheikh, {Mohammed Z.}",

note = "Funding Information: From the Division of Infectious Diseases and Epidemiology (Dr. Axelrod and Mr. Sheikh) and the Department of Ophthalmology (Dr. Newton), St. Luke's-Roosevelt Hospital Center, New York, New York; and the Department of Ophthalmology (Drs. Klein and Bergen), Hack-ensack Medical Center, Hackensack, New Jersey. This study was supported by a grant from Merck, Sharpe and Dohme Research Laboratories, West Point, Pennsylvania.",

year = "1987",

month = dec,

doi = "10.1016/0002-9394(87)90180-2",

language = "English (US)",

volume = "104",

pages = "649--653",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

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T1 - Penetration of imipenem into human aqueous and vitreous humor

AU - Axelrod, Judith L.

AU - Newton, James C.

AU - Klein, Richard M.

AU - Bergen, Robert L.

AU - Sheikh, Mohammed Z.

N1 - Funding Information: From the Division of Infectious Diseases and Epidemiology (Dr. Axelrod and Mr. Sheikh) and the Department of Ophthalmology (Dr. Newton), St. Luke's-Roosevelt Hospital Center, New York, New York; and the Department of Ophthalmology (Drs. Klein and Bergen), Hack-ensack Medical Center, Hackensack, New Jersey. This study was supported by a grant from Merck, Sharpe and Dohme Research Laboratories, West Point, Pennsylvania.

PY - 1987/12

Y1 - 1987/12

N2 - Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 μg/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 μg/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.

AB - Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 μg/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 μg/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.

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EP - 653

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 6

ER -

Penetration of imipenem into human aqueous and vitreous humor

Abstract

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