TY - JOUR
T1 - Pediatric obesity-related asthma
T2 - The role of metabolic dysregulation
AU - Vijayakanthi, Nandini
AU - Greally, John M.
AU - Rastogi, Deepa
N1 - Publisher Copyright:
© Copyright 2016 by the American Academy of Pediatrics.
PY - 2016/5
Y1 - 2016/5
N2 - The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.
AB - The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.
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U2 - 10.1542/peds.2015-0812
DO - 10.1542/peds.2015-0812
M3 - Article
C2 - 27244776
AN - SCOPUS:84969835497
SN - 0031-4005
VL - 137
JO - Pediatrics
JF - Pediatrics
IS - 5
M1 - e20150812
ER -