Pediatric obesity-related asthma: The role of metabolic dysregulation

Nandini Vijayakanthi, John M. Greally, Deepa Rastogi

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.

Original languageEnglish (US)
Article numbere20150812
JournalPediatrics
Volume137
Issue number5
DOIs
StatePublished - May 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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