Pediatric Nephrotic Syndrome: From the Simple to the Complex

Jerome C. Lane, Frederick J. Kaskel

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Remarkable advances have been made in the past decade in understanding the pathophysiology of idiopathic nephrotic syndrome. Although the initiating events leading to the onset of proteinuria still are not well defined, it has become increasingly clear that many glomerular diseases can be classified as podocytopathies, with injury to the podocyte playing a major role in the development and progression of disease. A complex interaction of immune system mediators, slit diaphragm signal transduction, podocyte injury and conformational change, and mediators of apoptosis and fibrosis determine the extent and nature of proteinuria and progression of glomerulosclerosis. New insights into the pathogenesis of idiopathic nephrotic syndrome likely will lead to innovative therapies and new approaches to management and prevention.

Original languageEnglish (US)
Pages (from-to)389-398
Number of pages10
JournalSeminars in Nephrology
Volume29
Issue number4
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Keywords

  • Nephrotic syndrome
  • focal segmental glomerulosclerosis
  • minimal change disease
  • nephrin
  • podocin
  • podocyte

ASJC Scopus subject areas

  • Nephrology

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