Pediatric Nephrotic Syndrome

From the Simple to the Complex

Jerome C. Lane, Frederick J. Kaskel

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Remarkable advances have been made in the past decade in understanding the pathophysiology of idiopathic nephrotic syndrome. Although the initiating events leading to the onset of proteinuria still are not well defined, it has become increasingly clear that many glomerular diseases can be classified as podocytopathies, with injury to the podocyte playing a major role in the development and progression of disease. A complex interaction of immune system mediators, slit diaphragm signal transduction, podocyte injury and conformational change, and mediators of apoptosis and fibrosis determine the extent and nature of proteinuria and progression of glomerulosclerosis. New insights into the pathogenesis of idiopathic nephrotic syndrome likely will lead to innovative therapies and new approaches to management and prevention.

Original languageEnglish (US)
Pages (from-to)389-398
Number of pages10
JournalSeminars in Nephrology
Volume29
Issue number4
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Podocytes
Nephrotic Syndrome
Proteinuria
Pediatrics
Investigational Therapies
Wounds and Injuries
Diaphragm
Disease Progression
Immune System
Signal Transduction
Fibrosis
Apoptosis
Congenital Nephrosis

Keywords

  • focal segmental glomerulosclerosis
  • minimal change disease
  • nephrin
  • Nephrotic syndrome
  • podocin
  • podocyte

ASJC Scopus subject areas

  • Nephrology

Cite this

Pediatric Nephrotic Syndrome : From the Simple to the Complex. / Lane, Jerome C.; Kaskel, Frederick J.

In: Seminars in Nephrology, Vol. 29, No. 4, 07.2009, p. 389-398.

Research output: Contribution to journalArticle

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