Pediatric heart transplantation across ABO blood type barriers: A case study

Rose J. Rodriguez; Linda J. Addonizio; Jacqueline M. Lamour; Seema Mital; Ralph Mosca; Lori J. West; Jenny C. Nova; Daphne T. Hsu

doi:10.1177/152692480501500209

Pediatric heart transplantation across ABO blood type barriers: A case study

Rose J. Rodriguez, Linda J. Addonizio, Jacqueline M. Lamour, Seema Mital, Ralph Mosca, Lori J. West, Jenny C. Nova, Daphne T. Hsu

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Heart transplantation with ABO blood type-incompatible donors has historically been contraindicated because of the high risk of an immediate hyperacute humoral graft rejection. The immature neonatal immune system presents an immunologic window that allows for breaching the ABO barrier before the natural development of anti-ABO antibodies. Information from a small series of neonates has demonstrated similar survival rates and posttransplant outcomes compared to ABO-compatible transplantations. In the posttransplant period, particular attention is placed on the surveillance of graft-specific antibody production and monitoring for immunologic signs and symptoms of early graft vasculopathy. This article presents a case study of a neonate with congenital heart disease who underwent one of the first successful ABO-incompatible heart transplantations in the United States.

Original language	English (US)
Pages (from-to)	161-165
Number of pages	5
Journal	Progress in Transplantation
Volume	15
Issue number	2
DOIs	https://doi.org/10.1177/152692480501500209
State	Published - Jun 1 2005
Externally published	Yes

ASJC Scopus subject areas

Transplantation

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title = "Pediatric heart transplantation across ABO blood type barriers: A case study",

abstract = "Heart transplantation with ABO blood type-incompatible donors has historically been contraindicated because of the high risk of an immediate hyperacute humoral graft rejection. The immature neonatal immune system presents an immunologic window that allows for breaching the ABO barrier before the natural development of anti-ABO antibodies. Information from a small series of neonates has demonstrated similar survival rates and posttransplant outcomes compared to ABO-compatible transplantations. In the posttransplant period, particular attention is placed on the surveillance of graft-specific antibody production and monitoring for immunologic signs and symptoms of early graft vasculopathy. This article presents a case study of a neonate with congenital heart disease who underwent one of the first successful ABO-incompatible heart transplantations in the United States.",

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AU - Addonizio, Linda J.

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AU - Mital, Seema

AU - Mosca, Ralph

AU - West, Lori J.

AU - Nova, Jenny C.

AU - Hsu, Daphne T.

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Pediatric heart transplantation across ABO blood type barriers: A case study

Abstract

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