Pediatric heart transplantation across ABO blood type barriers: A case study

Rose J. Rodriguez, Linda J. Addonizio, Jacqueline M. Lamour, Seema Mital, Ralph Mosca, Lori J. West, Jenny C. Nova, Daphne T. Hsu

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Heart transplantation with ABO blood type-incompatible donors has historically been contraindicated because of the high risk of an immediate hyperacute humoral graft rejection. The immature neonatal immune system presents an immunologic window that allows for breaching the ABO barrier before the natural development of anti-ABO antibodies. Information from a small series of neonates has demonstrated similar survival rates and posttransplant outcomes compared to ABO-compatible transplantations. In the posttransplant period, particular attention is placed on the surveillance of graft-specific antibody production and monitoring for immunologic signs and symptoms of early graft vasculopathy. This article presents a case study of a neonate with congenital heart disease who underwent one of the first successful ABO-incompatible heart transplantations in the United States.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalProgress in Transplantation
Volume15
Issue number2
StatePublished - Jun 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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    Rodriguez, R. J., Addonizio, L. J., Lamour, J. M., Mital, S., Mosca, R., West, L. J., Nova, J. C., & Hsu, D. T. (2005). Pediatric heart transplantation across ABO blood type barriers: A case study. Progress in Transplantation, 15(2), 161-165.