Pediatric Epilepsy: Age-Specific Responses to Antiepileptic Drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Antiepileptic drugs have been valuable therapeutic tools, but may have adverse effects. Their effects, whether therapeutic or adverse, may vary among subjects and can be age-specific. In this article, we focus on the GABAA signaling cascades and review the known age-related changes in its effects. The finding of sex-specific patterns in the ontogeny of GABAA signaling has enabled us to reveal factors, such as seizures and stress that modulate the biological age of the system. To cure epilepsy without side effects, it is important to implement therapies appropriate for the developmental stage of the targeted systems.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Basic Epilepsy Research
PublisherElsevier Inc.
Pages1025-1033
Number of pages9
ISBN (Print)9780123739612
DOIs
StatePublished - Jan 1 2009

Keywords

  • Age
  • Antiepileptic
  • Chloride cotransporter
  • Development
  • GABA
  • GABA receptor
  • Hippocampus
  • Seizure
  • Sex
  • Substantia nigra

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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