PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans

Arantza Barrios, Rajarshi Ghosh, Chunhui Fang, Scott W. Emmons, Maureen M. Barr

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states.

Original languageEnglish (US)
Pages (from-to)1675-1682
Number of pages8
JournalNature Neuroscience
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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