PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans

Arantza Barrios, Rajarshi Ghosh, Chunhui Fang, Scott W. Emmons, Maureen M. Barr

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states.

Original languageEnglish (US)
Pages (from-to)1675-1682
Number of pages8
JournalNature Neuroscience
Volume15
Issue number12
DOIs
StatePublished - Dec 2012

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Appetitive Behavior
Neuropeptides
Exploratory Behavior
Neurons
Secretin
Interneurons
Appetite
Nervous System
Decision Making
Ligands
Food

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans. / Barrios, Arantza; Ghosh, Rajarshi; Fang, Chunhui; Emmons, Scott W.; Barr, Maureen M.

In: Nature Neuroscience, Vol. 15, No. 12, 12.2012, p. 1675-1682.

Research output: Contribution to journalArticle

Barrios, Arantza ; Ghosh, Rajarshi ; Fang, Chunhui ; Emmons, Scott W. ; Barr, Maureen M. / PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans. In: Nature Neuroscience. 2012 ; Vol. 15, No. 12. pp. 1675-1682.
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