PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description

PCORnet Antibiotics Childhood Growth Study Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using health care data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet's inaugural observational studies. We sought to describe the processes used to integrate and analyze data from children across 36 participating institutions, the cohort characteristics, and prevalence of antibiotic use. Methods: We included children in the cohort if they had at least one same-day height and weight measured in each of 3 age periods: 1) before 12 months, 2) 12 to 30 months, and 3) after 24 months. We distributed statistical queries that each institution ran on its local version of the PCORnet Common Data Model, with aggregate data returned for analysis. We defined overweight or obesity as age- and sex-specific body mass index ≥85th percentile, obesity ≥95th percentile, and severe obesity ≥120% of the 95th percentile. Results: A total of 681,739 children met the cohort inclusion criteria, and participants were racially/ethnically diverse (24.9% black, 17.5% Hispanic). Before 24 months of age, 55.2% of children received at least one antibiotic prescription; 21.3% received a single antibiotic prescription; 14.3% received 4 or more; and 33.3% received a broad-spectrum antibiotic. Overweight and obesity prevalence was 27.6% at age 4 to <6 years (n = 362,044) and 36.2% at 9 to <11 years (n = 58,344). Conclusions: The PCORnet Antibiotics and Childhood Growth Study is a large national longitudinal observational study in a diverse population that will examine the relationship between early antibiotic use and subsequent growth patterns in children.

Original languageEnglish (US)
JournalAcademic Pediatrics
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Cohort Studies
Anti-Bacterial Agents
Growth
Obesity
Observational Studies
Prescriptions
Morbid Obesity
Health Services Research
Hispanic Americans
Longitudinal Studies
Body Mass Index
Weights and Measures
Research
Population

Keywords

  • antibiotics
  • body mass index
  • childhood growth
  • childhood obesity
  • electronic health records
  • research infrastructure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

PCORnet Antibiotics and Childhood Growth Study : Process for Cohort Creation and Cohort Description. / PCORnet Antibiotics Childhood Growth Study Group.

In: Academic Pediatrics, 01.01.2018.

Research output: Contribution to journalArticle

@article{b1f9f3758dca44cd93aac90d083b0802,
title = "PCORnet Antibiotics and Childhood Growth Study: Process for Cohort Creation and Cohort Description",
abstract = "Objectives: The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using health care data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet's inaugural observational studies. We sought to describe the processes used to integrate and analyze data from children across 36 participating institutions, the cohort characteristics, and prevalence of antibiotic use. Methods: We included children in the cohort if they had at least one same-day height and weight measured in each of 3 age periods: 1) before 12 months, 2) 12 to 30 months, and 3) after 24 months. We distributed statistical queries that each institution ran on its local version of the PCORnet Common Data Model, with aggregate data returned for analysis. We defined overweight or obesity as age- and sex-specific body mass index ≥85th percentile, obesity ≥95th percentile, and severe obesity ≥120{\%} of the 95th percentile. Results: A total of 681,739 children met the cohort inclusion criteria, and participants were racially/ethnically diverse (24.9{\%} black, 17.5{\%} Hispanic). Before 24 months of age, 55.2{\%} of children received at least one antibiotic prescription; 21.3{\%} received a single antibiotic prescription; 14.3{\%} received 4 or more; and 33.3{\%} received a broad-spectrum antibiotic. Overweight and obesity prevalence was 27.6{\%} at age 4 to <6 years (n = 362,044) and 36.2{\%} at 9 to <11 years (n = 58,344). Conclusions: The PCORnet Antibiotics and Childhood Growth Study is a large national longitudinal observational study in a diverse population that will examine the relationship between early antibiotic use and subsequent growth patterns in children.",
keywords = "antibiotics, body mass index, childhood growth, childhood obesity, electronic health records, research infrastructure",
author = "{PCORnet Antibiotics Childhood Growth Study Group} and Block, {Jason P.} and Bailey, {L. Charles} and Gillman, {Matthew W.} and Douglas Lunsford and Janne Boone-Heinonen and Cleveland, {Lauren P.} and Jonathan Finkelstein and Horgan, {Casie E.} and Melanie Jay and Reynolds, {Juliane S.} and Sturtevant, {Jessica L.} and Forrest, {Christopher B.} and William Adams and Brad Appelhans and Andrew Brickman and Jiang Bian and Daley, {Matthew F.} and Arthur Davidson and Amanda Dempsey and Dugas, {Lara R.} and Ihuoma Eneli and Fitzpatrick, {Stephanie L.} and William Heerman and Michael Horberg and Hsia, {Daniel S.} and Jenny Ingber and Isasi, {Carmen R.} and Janicke, {David M.} and Doug Kane and Elyse Kharbanda and David Meltzer and Messito, {Mary Jo} and Prakash Nadkarni and Kevin O'Bryan and Holly Peay and Jon Puro and Daksha Ranade and Goutham Rao and Alfredo Tirado-Ramos and Maria Rayas and Hanieh Razzaghi and Ricket, {Iben M.} and Marc Rosenman and Siegel, {Robert M.} and Tony Solomonides and Taveras, {Elsie M.} and Bradley Taylor and Veeral Tolia and Zachary Willis and Jeffrey VanWormer",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.acap.2018.02.008",
language = "English (US)",
journal = "Academic Pediatrics",
issn = "1876-2859",
publisher = "Elsevier Inc.",

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TY - JOUR

T1 - PCORnet Antibiotics and Childhood Growth Study

T2 - Process for Cohort Creation and Cohort Description

AU - PCORnet Antibiotics Childhood Growth Study Group

AU - Block, Jason P.

AU - Bailey, L. Charles

AU - Gillman, Matthew W.

AU - Lunsford, Douglas

AU - Boone-Heinonen, Janne

AU - Cleveland, Lauren P.

AU - Finkelstein, Jonathan

AU - Horgan, Casie E.

AU - Jay, Melanie

AU - Reynolds, Juliane S.

AU - Sturtevant, Jessica L.

AU - Forrest, Christopher B.

AU - Adams, William

AU - Appelhans, Brad

AU - Brickman, Andrew

AU - Bian, Jiang

AU - Daley, Matthew F.

AU - Davidson, Arthur

AU - Dempsey, Amanda

AU - Dugas, Lara R.

AU - Eneli, Ihuoma

AU - Fitzpatrick, Stephanie L.

AU - Heerman, William

AU - Horberg, Michael

AU - Hsia, Daniel S.

AU - Ingber, Jenny

AU - Isasi, Carmen R.

AU - Janicke, David M.

AU - Kane, Doug

AU - Kharbanda, Elyse

AU - Meltzer, David

AU - Messito, Mary Jo

AU - Nadkarni, Prakash

AU - O'Bryan, Kevin

AU - Peay, Holly

AU - Puro, Jon

AU - Ranade, Daksha

AU - Rao, Goutham

AU - Tirado-Ramos, Alfredo

AU - Rayas, Maria

AU - Razzaghi, Hanieh

AU - Ricket, Iben M.

AU - Rosenman, Marc

AU - Siegel, Robert M.

AU - Solomonides, Tony

AU - Taveras, Elsie M.

AU - Taylor, Bradley

AU - Tolia, Veeral

AU - Willis, Zachary

AU - VanWormer, Jeffrey

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using health care data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet's inaugural observational studies. We sought to describe the processes used to integrate and analyze data from children across 36 participating institutions, the cohort characteristics, and prevalence of antibiotic use. Methods: We included children in the cohort if they had at least one same-day height and weight measured in each of 3 age periods: 1) before 12 months, 2) 12 to 30 months, and 3) after 24 months. We distributed statistical queries that each institution ran on its local version of the PCORnet Common Data Model, with aggregate data returned for analysis. We defined overweight or obesity as age- and sex-specific body mass index ≥85th percentile, obesity ≥95th percentile, and severe obesity ≥120% of the 95th percentile. Results: A total of 681,739 children met the cohort inclusion criteria, and participants were racially/ethnically diverse (24.9% black, 17.5% Hispanic). Before 24 months of age, 55.2% of children received at least one antibiotic prescription; 21.3% received a single antibiotic prescription; 14.3% received 4 or more; and 33.3% received a broad-spectrum antibiotic. Overweight and obesity prevalence was 27.6% at age 4 to <6 years (n = 362,044) and 36.2% at 9 to <11 years (n = 58,344). Conclusions: The PCORnet Antibiotics and Childhood Growth Study is a large national longitudinal observational study in a diverse population that will examine the relationship between early antibiotic use and subsequent growth patterns in children.

AB - Objectives: The National Patient-Centered Clinical Research Network (PCORnet) supports observational and clinical research using health care data. The PCORnet Antibiotics and Childhood Growth Study is one of PCORnet's inaugural observational studies. We sought to describe the processes used to integrate and analyze data from children across 36 participating institutions, the cohort characteristics, and prevalence of antibiotic use. Methods: We included children in the cohort if they had at least one same-day height and weight measured in each of 3 age periods: 1) before 12 months, 2) 12 to 30 months, and 3) after 24 months. We distributed statistical queries that each institution ran on its local version of the PCORnet Common Data Model, with aggregate data returned for analysis. We defined overweight or obesity as age- and sex-specific body mass index ≥85th percentile, obesity ≥95th percentile, and severe obesity ≥120% of the 95th percentile. Results: A total of 681,739 children met the cohort inclusion criteria, and participants were racially/ethnically diverse (24.9% black, 17.5% Hispanic). Before 24 months of age, 55.2% of children received at least one antibiotic prescription; 21.3% received a single antibiotic prescription; 14.3% received 4 or more; and 33.3% received a broad-spectrum antibiotic. Overweight and obesity prevalence was 27.6% at age 4 to <6 years (n = 362,044) and 36.2% at 9 to <11 years (n = 58,344). Conclusions: The PCORnet Antibiotics and Childhood Growth Study is a large national longitudinal observational study in a diverse population that will examine the relationship between early antibiotic use and subsequent growth patterns in children.

KW - antibiotics

KW - body mass index

KW - childhood growth

KW - childhood obesity

KW - electronic health records

KW - research infrastructure

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U2 - 10.1016/j.acap.2018.02.008

DO - 10.1016/j.acap.2018.02.008

M3 - Article

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JO - Academic Pediatrics

JF - Academic Pediatrics

SN - 1876-2859

ER -