Patterns of genome evolution among the Microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and enterocytozoon bieneusi

Nicolas Corradi, Donna E. Akiyoshi, Hilary G. Morrison, Xiaochuan Feng, Louis M. Weiss, Saul Tzipori, Patrick J. Keeling

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Backgroud. Microsporidia are intracellular parasites that are highly-derived relatives of fungi. They have compacted genomes and, despite a high rate of sequence evolution, distantly related species can share high levels of gene order conservation. To date, only two species have been analysed in detail, and data from one of these largely consists of short genomic fragments. It is therefore difficult to determine how conservation has been maintained through microsporidian evolution, and impossible to identify whether certain regions are more prone to genomic stasis. Principal findings. Here, we analyse three large fragments of the Enterocytozoon bieneusi genome (in total 429 kbp), a species of medical significance. A total of 296 ORFs were identified, annotated and their context compared with Encephalitozoon cuniculi and Antonospora locustae. Overall, a high degree of conservation was found between all three species, and interestingly the level of conservation was similar in all three pairwise comparisons, despite the fact that A. locustae is more distantly related to E. cuniculi and E bieneusithan either are to each other. Conclusions/significance. Any two genes that are found together in any pair of genomes are more likely to be conserved in the third genome as well, suggesting that a core of genes tends to be conserved across the entire group. The mechanisms of rearrangments identified among microsporidian genomes were consistent with a very slow evolution of their architecture, as opposed to the very rapid sequence evolution reported for these parasites.

Original languageEnglish (US)
Article numbere1277
JournalPLoS One
Volume2
Issue number12
DOIs
StatePublished - Dec 5 2007

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Enterocytozoon
Encephalitozoon cuniculi
Microsporidia
Parasites
Genes
Genome
parasites
genome
Conservation
genomics
Gene Order
genes
Open Reading Frames
open reading frames
Fungi
fungi

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Patterns of genome evolution among the Microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and enterocytozoon bieneusi. / Corradi, Nicolas; Akiyoshi, Donna E.; Morrison, Hilary G.; Feng, Xiaochuan; Weiss, Louis M.; Tzipori, Saul; Keeling, Patrick J.

In: PLoS One, Vol. 2, No. 12, e1277, 05.12.2007.

Research output: Contribution to journalArticle

Corradi, Nicolas ; Akiyoshi, Donna E. ; Morrison, Hilary G. ; Feng, Xiaochuan ; Weiss, Louis M. ; Tzipori, Saul ; Keeling, Patrick J. / Patterns of genome evolution among the Microsporidian parasites Encephalitozoon cuniculi, Antonospora locustae and enterocytozoon bieneusi. In: PLoS One. 2007 ; Vol. 2, No. 12.
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