Patterning signals and proliferation in Drosophila imaginal discs

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Recent studies indicate that signaling pathways with well-known roles in patterning also directly regulate cell proliferation. During the differentiation of the retina, Hedgehog, Decapentaplegic, Notch and the EGF receptor regulate proliferation spatially through transcriptional regulation of string, dacapo, and as yet unidentified regulators of Retinoblastoma and Cyclin E/Cdk2 activities. In the developing wing, a novel response to discontinuities in Decapentaplegic signaling combines with concentration-dependent effects to achieve a uniform proliferation pattern in response to a Decapentaplegic gradient. Damage to growing tissues is repaired by transient Decapentaplegic and Wingless secretion from dying cells to induce compensatory proliferation. Diverse spatial patterns of fate specification and of proliferation can arise through distinct combinations of signaling pathways. Reminiscent of pattern formation, cell cycle effects of each signaling pathway differ in distinct developmental fields, making use of a variety of target genes.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume17
Issue number4
DOIs
StatePublished - Aug 2007

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Imaginal Discs
Cyclin E
Hedgehogs
Retinoblastoma
Epidermal Growth Factor Receptor
Drosophila
Retina
Cell Cycle
Cell Proliferation
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Patterning signals and proliferation in Drosophila imaginal discs. / Baker, Nicholas E.

In: Current Opinion in Genetics and Development, Vol. 17, No. 4, 08.2007, p. 287-293.

Research output: Contribution to journalArticle

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