Patient-perceived impact of resective epilepsy surgery

P. S. Chin, A. T. Berg, S. S. Spencer, M. L. Lee, Shlomo Shinnar, M. R. Sperling, J. T. Langfitt, T. S. Walczak, S. V. Pacia, C. W. Bazil, S. Vassar, B. G. Vickrey

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To evaluate the patient-perceived impact of resective epilepsy surgery, a key outcome to consider in evaluating such a highly invasive, elective procedure. METHODS: Impact measures obtained from 396 patients in a multicenter cohort study of resective epilepsy surgery included (1) willingness to undergo surgery if that decision could be made again and (2) the overall impact of surgery on the patient's life. Predictors of impact were analyzed using multivariate ordinal logistic regression. RESULTS: Of study participants, 73.8%, 77.4%, and 75.5% would definitely undergo surgery again and 78.2%, 80.2%, and 79.1% reported a very strong or strong positive overall impact of surgery at 3, 12, and 24 months. Multivariate ordinal logistic regression showed that seizure freedom predicted more positive perceptions at 3, 12, and 24 months (all p < 0.04). Becoming employed was uniquely associated with willingness to undergo surgery again and with overall impact at 24 months (all p < 0.05), but only a net 7% of the cohort improved their employment status. Right-sided resection (at 12 and 24 months, p < 0.005) and female gender (at 3 and 12 months, p = 0.006) were each positively associated with perceived overall impact. CONCLUSIONS: Most epilepsy surgery patients report a positive overall impact of the procedure on their lives and a high willingness to undergo surgery again if that choice could be made. Seizure-free individuals express consistently more positive perceptions of the procedure. Findings suggest that it is important to make early efforts to reintegrate epilepsy surgery patients into employment.

Original languageEnglish (US)
Pages (from-to)1882-1887
Number of pages6
JournalNeurology
Volume66
Issue number12
DOIs
StatePublished - Jun 2006

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Epilepsy
Seizures
Logistic Models
Multicenter Studies
Cohort Studies

ASJC Scopus subject areas

  • Neuroscience(all)

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Chin, P. S., Berg, A. T., Spencer, S. S., Lee, M. L., Shinnar, S., Sperling, M. R., ... Vickrey, B. G. (2006). Patient-perceived impact of resective epilepsy surgery. Neurology, 66(12), 1882-1887. https://doi.org/10.1212/01.wnl.0000219729.08924.54

Patient-perceived impact of resective epilepsy surgery. / Chin, P. S.; Berg, A. T.; Spencer, S. S.; Lee, M. L.; Shinnar, Shlomo; Sperling, M. R.; Langfitt, J. T.; Walczak, T. S.; Pacia, S. V.; Bazil, C. W.; Vassar, S.; Vickrey, B. G.

In: Neurology, Vol. 66, No. 12, 06.2006, p. 1882-1887.

Research output: Contribution to journalArticle

Chin, PS, Berg, AT, Spencer, SS, Lee, ML, Shinnar, S, Sperling, MR, Langfitt, JT, Walczak, TS, Pacia, SV, Bazil, CW, Vassar, S & Vickrey, BG 2006, 'Patient-perceived impact of resective epilepsy surgery', Neurology, vol. 66, no. 12, pp. 1882-1887. https://doi.org/10.1212/01.wnl.0000219729.08924.54
Chin PS, Berg AT, Spencer SS, Lee ML, Shinnar S, Sperling MR et al. Patient-perceived impact of resective epilepsy surgery. Neurology. 2006 Jun;66(12):1882-1887. https://doi.org/10.1212/01.wnl.0000219729.08924.54
Chin, P. S. ; Berg, A. T. ; Spencer, S. S. ; Lee, M. L. ; Shinnar, Shlomo ; Sperling, M. R. ; Langfitt, J. T. ; Walczak, T. S. ; Pacia, S. V. ; Bazil, C. W. ; Vassar, S. ; Vickrey, B. G. / Patient-perceived impact of resective epilepsy surgery. In: Neurology. 2006 ; Vol. 66, No. 12. pp. 1882-1887.
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abstract = "OBJECTIVE: To evaluate the patient-perceived impact of resective epilepsy surgery, a key outcome to consider in evaluating such a highly invasive, elective procedure. METHODS: Impact measures obtained from 396 patients in a multicenter cohort study of resective epilepsy surgery included (1) willingness to undergo surgery if that decision could be made again and (2) the overall impact of surgery on the patient's life. Predictors of impact were analyzed using multivariate ordinal logistic regression. RESULTS: Of study participants, 73.8{\%}, 77.4{\%}, and 75.5{\%} would definitely undergo surgery again and 78.2{\%}, 80.2{\%}, and 79.1{\%} reported a very strong or strong positive overall impact of surgery at 3, 12, and 24 months. Multivariate ordinal logistic regression showed that seizure freedom predicted more positive perceptions at 3, 12, and 24 months (all p < 0.04). Becoming employed was uniquely associated with willingness to undergo surgery again and with overall impact at 24 months (all p < 0.05), but only a net 7{\%} of the cohort improved their employment status. Right-sided resection (at 12 and 24 months, p < 0.005) and female gender (at 3 and 12 months, p = 0.006) were each positively associated with perceived overall impact. CONCLUSIONS: Most epilepsy surgery patients report a positive overall impact of the procedure on their lives and a high willingness to undergo surgery again if that choice could be made. Seizure-free individuals express consistently more positive perceptions of the procedure. Findings suggest that it is important to make early efforts to reintegrate epilepsy surgery patients into employment.",
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AU - Chin, P. S.

AU - Berg, A. T.

AU - Spencer, S. S.

AU - Lee, M. L.

AU - Shinnar, Shlomo

AU - Sperling, M. R.

AU - Langfitt, J. T.

AU - Walczak, T. S.

AU - Pacia, S. V.

AU - Bazil, C. W.

AU - Vassar, S.

AU - Vickrey, B. G.

PY - 2006/6

Y1 - 2006/6

N2 - OBJECTIVE: To evaluate the patient-perceived impact of resective epilepsy surgery, a key outcome to consider in evaluating such a highly invasive, elective procedure. METHODS: Impact measures obtained from 396 patients in a multicenter cohort study of resective epilepsy surgery included (1) willingness to undergo surgery if that decision could be made again and (2) the overall impact of surgery on the patient's life. Predictors of impact were analyzed using multivariate ordinal logistic regression. RESULTS: Of study participants, 73.8%, 77.4%, and 75.5% would definitely undergo surgery again and 78.2%, 80.2%, and 79.1% reported a very strong or strong positive overall impact of surgery at 3, 12, and 24 months. Multivariate ordinal logistic regression showed that seizure freedom predicted more positive perceptions at 3, 12, and 24 months (all p < 0.04). Becoming employed was uniquely associated with willingness to undergo surgery again and with overall impact at 24 months (all p < 0.05), but only a net 7% of the cohort improved their employment status. Right-sided resection (at 12 and 24 months, p < 0.005) and female gender (at 3 and 12 months, p = 0.006) were each positively associated with perceived overall impact. CONCLUSIONS: Most epilepsy surgery patients report a positive overall impact of the procedure on their lives and a high willingness to undergo surgery again if that choice could be made. Seizure-free individuals express consistently more positive perceptions of the procedure. Findings suggest that it is important to make early efforts to reintegrate epilepsy surgery patients into employment.

AB - OBJECTIVE: To evaluate the patient-perceived impact of resective epilepsy surgery, a key outcome to consider in evaluating such a highly invasive, elective procedure. METHODS: Impact measures obtained from 396 patients in a multicenter cohort study of resective epilepsy surgery included (1) willingness to undergo surgery if that decision could be made again and (2) the overall impact of surgery on the patient's life. Predictors of impact were analyzed using multivariate ordinal logistic regression. RESULTS: Of study participants, 73.8%, 77.4%, and 75.5% would definitely undergo surgery again and 78.2%, 80.2%, and 79.1% reported a very strong or strong positive overall impact of surgery at 3, 12, and 24 months. Multivariate ordinal logistic regression showed that seizure freedom predicted more positive perceptions at 3, 12, and 24 months (all p < 0.04). Becoming employed was uniquely associated with willingness to undergo surgery again and with overall impact at 24 months (all p < 0.05), but only a net 7% of the cohort improved their employment status. Right-sided resection (at 12 and 24 months, p < 0.005) and female gender (at 3 and 12 months, p = 0.006) were each positively associated with perceived overall impact. CONCLUSIONS: Most epilepsy surgery patients report a positive overall impact of the procedure on their lives and a high willingness to undergo surgery again if that choice could be made. Seizure-free individuals express consistently more positive perceptions of the procedure. Findings suggest that it is important to make early efforts to reintegrate epilepsy surgery patients into employment.

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