Pathways for mRNA localization in the cytoplasm

Kevin Czaplinski, Robert H. Singer

Research output: Contribution to journalReview article

83 Scopus citations

Abstract

Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.

Original languageEnglish (US)
Pages (from-to)687-693
Number of pages7
JournalTrends in Biochemical Sciences
Volume31
Issue number12
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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