Pathways for mRNA localization in the cytoplasm

Kevin Czaplinski; Robert H. Singer

doi:10.1016/j.tibs.2006.10.007

Pathways for mRNA localization in the cytoplasm

Kevin Czaplinski, Robert H. Singer

Cell Biology

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

Abstract

Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.

Original language	English (US)
Pages (from-to)	687-693
Number of pages	7
Journal	Trends in Biochemical Sciences
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.tibs.2006.10.007
State	Published - Dec 2006

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2006.10.007

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title = "Pathways for mRNA localization in the cytoplasm",

abstract = "Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.",

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AB - Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.

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Pathways for mRNA localization in the cytoplasm

Abstract

ASJC Scopus subject areas

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