Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the experimental and clinical data on the pathophysiology of FSGS.
- Animal models
- Focal segmental glomerulosclerosis (FSGS)
- Nephrotics yndrome
- Transforming growth factor (TGFβ)
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health