Pathophysiologic basis for the medical management of portal hypertension

Fred F. Poordad, Samuel H. Sigal, Robert S. Brown

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.

Original languageEnglish (US)
Pages (from-to)453-467
Number of pages15
JournalExpert Opinion on Pharmacotherapy
Volume10
Issue number3
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

Portal Hypertension
Portal Pressure
Therapeutics
Liver Diseases
Fibrosis
Quality of Life
Mortality

Keywords

  • Ascites
  • Cirrhosis
  • Fibrosis
  • Hepatic encephalopathy
  • Hepatology
  • Hepatorenal syndrome
  • Liver
  • Portal hypertension
  • Portal vein
  • Variceal bleeding
  • Varices

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pathophysiologic basis for the medical management of portal hypertension. / Poordad, Fred F.; Sigal, Samuel H.; Brown, Robert S.

In: Expert Opinion on Pharmacotherapy, Vol. 10, No. 3, 02.2009, p. 453-467.

Research output: Contribution to journalReview article

@article{e29f64279a61462d978d35ebdf180084,
title = "Pathophysiologic basis for the medical management of portal hypertension",
abstract = "Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.",
keywords = "Ascites, Cirrhosis, Fibrosis, Hepatic encephalopathy, Hepatology, Hepatorenal syndrome, Liver, Portal hypertension, Portal vein, Variceal bleeding, Varices",
author = "Poordad, {Fred F.} and Sigal, {Samuel H.} and Brown, {Robert S.}",
year = "2009",
month = "2",
doi = "10.1517/14656560802707853",
language = "English (US)",
volume = "10",
pages = "453--467",
journal = "Expert Opinion on Pharmacotherapy",
issn = "1465-6566",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Pathophysiologic basis for the medical management of portal hypertension

AU - Poordad, Fred F.

AU - Sigal, Samuel H.

AU - Brown, Robert S.

PY - 2009/2

Y1 - 2009/2

N2 - Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.

AB - Background: Portal hypertension is a potentially life-threatening complication of cirrhosis, resulting from increased intrahepatic resistance and portal inflow. Objective: Given the complex nature of this disorder, a more complete understanding of the pathophysiology of portal hypertension is necessary to develop new therapies that target specific pathways that regulate portal pressure. Methods: This review is based on a literature search of published articles and abstracts on the pathophysiology of portal hypertension, its complications and its treatment. Results/conclusion: A number of therapies have been developed or are under investigation for the treatment of portal hypertension and its complications. These agents may reduce mortality and improve quality of life for patients with advanced liver disease.

KW - Ascites

KW - Cirrhosis

KW - Fibrosis

KW - Hepatic encephalopathy

KW - Hepatology

KW - Hepatorenal syndrome

KW - Liver

KW - Portal hypertension

KW - Portal vein

KW - Variceal bleeding

KW - Varices

UR - http://www.scopus.com/inward/record.url?scp=65649104408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649104408&partnerID=8YFLogxK

U2 - 10.1517/14656560802707853

DO - 10.1517/14656560802707853

M3 - Review article

C2 - 19191681

AN - SCOPUS:65649104408

VL - 10

SP - 453

EP - 467

JO - Expert Opinion on Pharmacotherapy

JF - Expert Opinion on Pharmacotherapy

SN - 1465-6566

IS - 3

ER -