TY - JOUR
T1 - Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments
AU - Valdez, Alessandro F.
AU - Miranda, Daniel Zamith
AU - Guimarães, Allan Jefferson
AU - Nimrichter, Leonardo
AU - Nosanchuk, Joshua D.
N1 - Funding Information:
This work was supported by grants from the Brazilian agency Conselho Nacional de Desenvolvimento Científico e Tecnológico (311179/2017-7 and 408711/2017-7 to L.N.; 311470/2018-1 to AJG), FAPERJ (E-26/202.809/2018 to LN, E-26/202.696/2018 and E-26/202.760/2015 to AJG). AFV was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001). J.D.N. and D.Z.M. were supported in part by NIH R21 AI124797. The authors would like to acknowledge Linus Mendes for valuable comments and advice.
Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the disease is particularly life-threatening in immunocompromised patients, with a wide range of clinical manifestations depending on the inoculum and virulence of the infecting strain. In this review, we discuss the established virulence factors and pathogenesis traits that make H. capsulatum highly adapted to a wide variety of hosts, including mammals. Understanding and integrating these mechanisms is a key step toward devising new preventative and therapeutic interventions.
AB - Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the disease is particularly life-threatening in immunocompromised patients, with a wide range of clinical manifestations depending on the inoculum and virulence of the infecting strain. In this review, we discuss the established virulence factors and pathogenesis traits that make H. capsulatum highly adapted to a wide variety of hosts, including mammals. Understanding and integrating these mechanisms is a key step toward devising new preventative and therapeutic interventions.
KW - Histoplasma capsulatum
KW - dimorphism
KW - histoplasmosis
KW - intracellular parasitism
KW - virulence
UR - http://www.scopus.com/inward/record.url?scp=85140836529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140836529&partnerID=8YFLogxK
U2 - 10.1080/21505594.2022.2137987
DO - 10.1080/21505594.2022.2137987
M3 - Article
C2 - 36266777
AN - SCOPUS:85140836529
SN - 2150-5594
VL - 13
SP - 1900
EP - 1919
JO - Virulence
JF - Virulence
IS - 1
ER -
