Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments

Alessandro F. Valdez, Daniel Zamith Miranda, Allan Jefferson Guimarães, Leonardo Nimrichter, Joshua D. Nosanchuk

Research output: Contribution to journalArticlepeer-review

Abstract

Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the disease is particularly life-threatening in immunocompromised patients, with a wide range of clinical manifestations depending on the inoculum and virulence of the infecting strain. In this review, we discuss the established virulence factors and pathogenesis traits that make H. capsulatum highly adapted to a wide variety of hosts, including mammals. Understanding and integrating these mechanisms is a key step toward devising new preventative and therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)1900-1919
Number of pages20
JournalVirulence
Volume13
Issue number1
DOIs
StatePublished - 2022

Keywords

  • dimorphism
  • Histoplasma capsulatum
  • histoplasmosis
  • intracellular parasitism
  • virulence

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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