Pathogenic significance and diagnostic value of lupus autoantibodies

Yaron Tomer, D. Buskila, Y. Shoenfeld

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

Original languageEnglish (US)
Pages (from-to)293-306
Number of pages14
JournalInternational Archives of Allergy and Immunology
Volume100
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Autoantibodies
Anti-Idiotypic Antibodies
Phospholipids
Antibodies
DNA

Keywords

  • Anti-cardiolipin
  • Anti-DNA
  • Autoantibodies
  • Autoimmunity
  • Rheumatoid factor
  • RNP
  • SLE
  • SSA
  • SSB

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Pathogenic significance and diagnostic value of lupus autoantibodies. / Tomer, Yaron; Buskila, D.; Shoenfeld, Y.

In: International Archives of Allergy and Immunology, Vol. 100, No. 4, 1993, p. 293-306.

Research output: Contribution to journalArticle

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