Pathogenic significance and diagnostic value of lupus autoantibodies

Y. Tomer, D. Buskila, Y. Shoenfeld

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

Original languageEnglish (US)
Pages (from-to)293-306
Number of pages14
JournalInternational Archives of Allergy and Immunology
Volume100
Issue number4
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

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Keywords

  • Anti-DNA
  • Anti-cardiolipin
  • Autoantibodies
  • Autoimmunity
  • RNP
  • Rheumatoid factor
  • SLE
  • SSA
  • SSB

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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