Abstract
Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 293-306 |
| Number of pages | 14 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 100 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
Keywords
- Anti-DNA
- Anti-cardiolipin
- Autoantibodies
- Autoimmunity
- RNP
- Rheumatoid factor
- SLE
- SSA
- SSB
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology