Abstract
Primary biliary cirrhosis is a multifactor autoimmune disease characterized by hepatic and systemic manifestations, with immune system dysregulation and abnormalities in the hepatic metabolism of bile salts, lipids, and nutrients, as well as destruction of membrane lipids and mitochondrial dysfunction. Both oxidative and nitrosative stress are associated with ongoing manifestations of the disease. In particular, abnormalities in nitric oxide metabolism and thiol oxidation already occur at early stages, thus leading to the hypothesis that these biochemical events play a pathogenic role in primary biliary cirrhosis. Moreover, the association of these metabolic abnormalities with the progression of the disease may indicate some biochemical parameters as early diagnostic markers of disease evolution, and may open up the potential for pharmacological intervention to inhibit intra- and extra-cellular stress events for resuming hepatocellular functions. The following paragraphs summarize the current knowledge by outlining molecular mechanisms of the disease related to these stress events.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5746-5759 |
| Number of pages | 14 |
| Journal | World Journal of Gastroenterology |
| Volume | 20 |
| Issue number | 19 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
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Keywords
- Aquaporins
- Bile salts
- Chronic cholestasis
- Glutathione
- Mitochondria
- Nitrosothiols
- Nitrotyrosine
- Protein sulfhydryls
- Thioredoxin
ASJC Scopus subject areas
- Gastroenterology
Cite this
Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis. / Grattagliano, Ignazio; Calamita, Giuseppe; Cocco, Tiziana; Wang, David Q.H.; Portincasa, Piero.
In: World Journal of Gastroenterology, Vol. 20, No. 19, 01.01.2014, p. 5746-5759.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis
AU - Grattagliano, Ignazio
AU - Calamita, Giuseppe
AU - Cocco, Tiziana
AU - Wang, David Q.H.
AU - Portincasa, Piero
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Primary biliary cirrhosis is a multifactor autoimmune disease characterized by hepatic and systemic manifestations, with immune system dysregulation and abnormalities in the hepatic metabolism of bile salts, lipids, and nutrients, as well as destruction of membrane lipids and mitochondrial dysfunction. Both oxidative and nitrosative stress are associated with ongoing manifestations of the disease. In particular, abnormalities in nitric oxide metabolism and thiol oxidation already occur at early stages, thus leading to the hypothesis that these biochemical events play a pathogenic role in primary biliary cirrhosis. Moreover, the association of these metabolic abnormalities with the progression of the disease may indicate some biochemical parameters as early diagnostic markers of disease evolution, and may open up the potential for pharmacological intervention to inhibit intra- and extra-cellular stress events for resuming hepatocellular functions. The following paragraphs summarize the current knowledge by outlining molecular mechanisms of the disease related to these stress events.
AB - Primary biliary cirrhosis is a multifactor autoimmune disease characterized by hepatic and systemic manifestations, with immune system dysregulation and abnormalities in the hepatic metabolism of bile salts, lipids, and nutrients, as well as destruction of membrane lipids and mitochondrial dysfunction. Both oxidative and nitrosative stress are associated with ongoing manifestations of the disease. In particular, abnormalities in nitric oxide metabolism and thiol oxidation already occur at early stages, thus leading to the hypothesis that these biochemical events play a pathogenic role in primary biliary cirrhosis. Moreover, the association of these metabolic abnormalities with the progression of the disease may indicate some biochemical parameters as early diagnostic markers of disease evolution, and may open up the potential for pharmacological intervention to inhibit intra- and extra-cellular stress events for resuming hepatocellular functions. The following paragraphs summarize the current knowledge by outlining molecular mechanisms of the disease related to these stress events.
KW - Aquaporins
KW - Bile salts
KW - Chronic cholestasis
KW - Glutathione
KW - Mitochondria
KW - Nitrosothiols
KW - Nitrotyrosine
KW - Protein sulfhydryls
KW - Thioredoxin
UR - http://www.scopus.com/inward/record.url?scp=84901194707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901194707&partnerID=8YFLogxK
U2 - 10.3748/wjg.v20.i19.5746
DO - 10.3748/wjg.v20.i19.5746
M3 - Article
VL - 20
SP - 5746
EP - 5759
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 19
ER -