Pathogenesis of Chagas disease: Time to move on

Fabiana S. Machado, Kevin M. Tyler, Fatima Brant, Lisia Esper, Mauro M. Teixeira, Herbert B. Tanowitz

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Trypanosoma cruzi is the etiologic agent of Chagas disease. The contributions of parasite and immune system for disease pathogenesis remain unresolved and controversial. The possibility that Chagas disease was an autoimmune progression triggered by T. cruzi infection led some to question the benefit of treating chronically T. cruzi-infected persons with drugs. Furthermore, it provided the rationale for not investing in research aimed at a vaccine which might carry a risk of inducing autoimmunity or exacerbating inflammation. This viewpoint was adopted by cash-strapped health systems in the developing economies where the disease is endemic and has been repeatedly challenged by researchers and clinicians in recent years and there is now a considerable body of evidence and broad consensus that parasite persistence is requisite for pathogenesis and that antiparasitic immunity can be protective against T. cruzi pathogenesis without eliciting autoimmune pathology. Thus, treatment of chronically infected patients is likely to yield positive outcomes and efforts to understand immunity and vaccine development should be recognized as a priority area of research for Chagas disease.

Original languageEnglish (US)
Pages (from-to)1743-1758
Number of pages16
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number5
StatePublished - Jan 1 2012

Keywords

  • Autoimmunity
  • Cardiac disease
  • Chagas disease
  • Chemokines
  • Cytokines
  • Immunity
  • Inflammation
  • Myocardial inflammation
  • Review
  • Toll-like receptors
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Machado, F. S., Tyler, K. M., Brant, F., Esper, L., Teixeira, M. M., & Tanowitz, H. B. (2012). Pathogenesis of Chagas disease: Time to move on. Frontiers in Bioscience - Elite, 4 E(5), 1743-1758.