Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection

Á L. Rosas, Joshua D. Nosanchuk, A. Casadevall

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.

Original languageEnglish (US)
Pages (from-to)3410-3412
Number of pages3
JournalInfection and Immunity
Volume69
Issue number5
DOIs
StatePublished - 2001

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Cryptococcus neoformans
Passive Immunization
Melanins
Monoclonal Antibodies
Infection
Antibodies
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection. / Rosas, Á L.; Nosanchuk, Joshua D.; Casadevall, A.

In: Infection and Immunity, Vol. 69, No. 5, 2001, p. 3410-3412.

Research output: Contribution to journalArticle

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