Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection

Á L. Rosas, J. D. Nosanchuk, A. Casadevall

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.

Original languageEnglish (US)
Pages (from-to)3410-3412
Number of pages3
JournalInfection and immunity
Volume69
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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