Partitioning the heart: Mechanisms of cardiac septation and valve development

Chien Jung Lin, Chieh Yu Lin, Chen Hao Chen, Bin Zhou, Ching Pin Chang

Research output: Contribution to journalReview article

97 Scopus citations

Abstract

Heart malformations are common congenital defects in humans. Many congenital heart defects involve anomalies in cardiac septation or valve development, and understanding the developmental mechanisms that underlie the formation of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart.

Original languageEnglish (US)
Pages (from-to)3277-3299
Number of pages23
JournalDevelopment (Cambridge)
Volume139
Issue number18
DOIs
StatePublished - Sep 15 2012

Keywords

  • Cardiac septation
  • Congenital heart disease
  • Heart development
  • Signaling
  • Transcription
  • Valve development

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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