Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: A meta-analysis

Dominik D. Alexander, Michael D. Cabana

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Objective: A reduced risk of atopic dermatitis (AD) among healthy infants who received 100% whey protein partially hydrolyzed formula (PHF-W) compared with intact protein cow's milk formula (CMF), has been reported in several studies. To validate these observations and estimate the magnitude of this potential association with greater statistical precision, we conducted a meta-analysis of clinical trial and intervention studies. Materials and Methods: A total of 18 articles representing 12 independent study populations met our inclusion criteria. Results: A statistically significant 44% (summary relative risk estimate [SRRE] = 0.56, 95% confidence interval 0.40-0.77) reduced risk of atopic manifestations, which included AD, was found among infants receiving PHF-W compared with infants receiving CMF. In a subanalysis of 4 studies that reported results specifically for AD and that were considered of superior methodological quality, the incidence of AD was reduced by 55% (SRRE = 0.45, 95% confidence interval 0.30-0.70). Conclusions: Regardless of study design, infant population, follow-up time, or study location, individual study findings were consistent because a reduced incidence of AD was reported in all of the reviewed studies. Exclusive breast-feeding should be encouraged as the standard for infant nutrition in the first months of life. For infants who are not exclusively breast-fed, feeding with PHF-W instead of CMF reduces the risk of AD in infants, particularly in infants with a family history of allergy.

Original languageEnglish (US)
Pages (from-to)422-430
Number of pages9
JournalJournal of pediatric gastroenterology and nutrition
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Fingerprint

Infant Formula
Atopic Dermatitis
Meta-Analysis
Breast Feeding
Milk
Confidence Intervals
Whey Proteins
Milk Proteins
Incidence
Population
Hypersensitivity
Clinical Trials

Keywords

  • Allergy
  • Atopic dermatitis
  • Infant formula
  • Meta-analysis
  • Nutrition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis : A meta-analysis. / Alexander, Dominik D.; Cabana, Michael D.

In: Journal of pediatric gastroenterology and nutrition, Vol. 50, No. 4, 01.04.2010, p. 422-430.

Research output: Contribution to journalArticle

@article{6952ea59a13045c59c8df9b478536831,
title = "Partially hydrolyzed 100{\%} whey protein infant formula and reduced risk of atopic dermatitis: A meta-analysis",
abstract = "Objective: A reduced risk of atopic dermatitis (AD) among healthy infants who received 100{\%} whey protein partially hydrolyzed formula (PHF-W) compared with intact protein cow's milk formula (CMF), has been reported in several studies. To validate these observations and estimate the magnitude of this potential association with greater statistical precision, we conducted a meta-analysis of clinical trial and intervention studies. Materials and Methods: A total of 18 articles representing 12 independent study populations met our inclusion criteria. Results: A statistically significant 44{\%} (summary relative risk estimate [SRRE] = 0.56, 95{\%} confidence interval 0.40-0.77) reduced risk of atopic manifestations, which included AD, was found among infants receiving PHF-W compared with infants receiving CMF. In a subanalysis of 4 studies that reported results specifically for AD and that were considered of superior methodological quality, the incidence of AD was reduced by 55{\%} (SRRE = 0.45, 95{\%} confidence interval 0.30-0.70). Conclusions: Regardless of study design, infant population, follow-up time, or study location, individual study findings were consistent because a reduced incidence of AD was reported in all of the reviewed studies. Exclusive breast-feeding should be encouraged as the standard for infant nutrition in the first months of life. For infants who are not exclusively breast-fed, feeding with PHF-W instead of CMF reduces the risk of AD in infants, particularly in infants with a family history of allergy.",
keywords = "Allergy, Atopic dermatitis, Infant formula, Meta-analysis, Nutrition",
author = "Alexander, {Dominik D.} and Cabana, {Michael D.}",
year = "2010",
month = "4",
day = "1",
doi = "10.1097/MPG.0b013e3181cea52b",
language = "English (US)",
volume = "50",
pages = "422--430",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis

T2 - A meta-analysis

AU - Alexander, Dominik D.

AU - Cabana, Michael D.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Objective: A reduced risk of atopic dermatitis (AD) among healthy infants who received 100% whey protein partially hydrolyzed formula (PHF-W) compared with intact protein cow's milk formula (CMF), has been reported in several studies. To validate these observations and estimate the magnitude of this potential association with greater statistical precision, we conducted a meta-analysis of clinical trial and intervention studies. Materials and Methods: A total of 18 articles representing 12 independent study populations met our inclusion criteria. Results: A statistically significant 44% (summary relative risk estimate [SRRE] = 0.56, 95% confidence interval 0.40-0.77) reduced risk of atopic manifestations, which included AD, was found among infants receiving PHF-W compared with infants receiving CMF. In a subanalysis of 4 studies that reported results specifically for AD and that were considered of superior methodological quality, the incidence of AD was reduced by 55% (SRRE = 0.45, 95% confidence interval 0.30-0.70). Conclusions: Regardless of study design, infant population, follow-up time, or study location, individual study findings were consistent because a reduced incidence of AD was reported in all of the reviewed studies. Exclusive breast-feeding should be encouraged as the standard for infant nutrition in the first months of life. For infants who are not exclusively breast-fed, feeding with PHF-W instead of CMF reduces the risk of AD in infants, particularly in infants with a family history of allergy.

AB - Objective: A reduced risk of atopic dermatitis (AD) among healthy infants who received 100% whey protein partially hydrolyzed formula (PHF-W) compared with intact protein cow's milk formula (CMF), has been reported in several studies. To validate these observations and estimate the magnitude of this potential association with greater statistical precision, we conducted a meta-analysis of clinical trial and intervention studies. Materials and Methods: A total of 18 articles representing 12 independent study populations met our inclusion criteria. Results: A statistically significant 44% (summary relative risk estimate [SRRE] = 0.56, 95% confidence interval 0.40-0.77) reduced risk of atopic manifestations, which included AD, was found among infants receiving PHF-W compared with infants receiving CMF. In a subanalysis of 4 studies that reported results specifically for AD and that were considered of superior methodological quality, the incidence of AD was reduced by 55% (SRRE = 0.45, 95% confidence interval 0.30-0.70). Conclusions: Regardless of study design, infant population, follow-up time, or study location, individual study findings were consistent because a reduced incidence of AD was reported in all of the reviewed studies. Exclusive breast-feeding should be encouraged as the standard for infant nutrition in the first months of life. For infants who are not exclusively breast-fed, feeding with PHF-W instead of CMF reduces the risk of AD in infants, particularly in infants with a family history of allergy.

KW - Allergy

KW - Atopic dermatitis

KW - Infant formula

KW - Meta-analysis

KW - Nutrition

UR - http://www.scopus.com/inward/record.url?scp=77950242636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950242636&partnerID=8YFLogxK

U2 - 10.1097/MPG.0b013e3181cea52b

DO - 10.1097/MPG.0b013e3181cea52b

M3 - Article

C2 - 20216095

AN - SCOPUS:77950242636

VL - 50

SP - 422

EP - 430

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 4

ER -