Partial Splenic Embolization Is a Safe and Effective Alternative in the Management of Portal Hypertension in Children

Jennifer Vittorio, Katherine Orellana, Mercedes Martinez, Nadia Ovchinsky, Peter Schlossberg, Adam Griesemer, Steven Lobritto

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: There are multiple approaches to manage the clinical complications of portal hypertension (PHTN) to treat/prevent spontaneous hemorrhage by mitigating thrombocytopenia. No single approach is ideal for all patients given the heterogeneity of this population. Our goal was to determine whether partial splenic embolization (PSE) was safe and effective in the pediatric population. METHODS: This is a retrospective review of our single-center experience for all patients ages 0 to 21 who underwent PSE between January 2010 and August 2017. The embolized splenic volume targeted was 60% to 70%. RESULTS: Twenty-six patients underwent PSE due to thrombocytopenia and/or recurrent variceal bleeding. Patients ranged in age from 18 months to 20 years (mean 13.1 years). The median platelet count before PSE was 53.0 (×10/L). The platelet count improved after PSE with values >100,000 in 21 patients (80.8%). Children with prior esophageal varices showed improvement after PSE with only 9 (34.6%) requiring further endoscopic therapy. After PSE, patients developed transient abdominal pain, distention, fever, and perisplenic fluid collections. Serious complications such as splenic abscess, splenic rupture, bleeding, pancreatic infarction, opportunistic infection, or death were not observed. One patient experienced thrombotic complications after PSE and was later diagnosed with myelodysplastic syndrome. CONCLUSIONS: PSE is a safe and effective alternative in the management of pediatric PHTN in select populations. PSE may be a favorable alternative to splenectomy and portal systemic shunting because it preserves functional spleen mass and avoids postprocedure accelerated liver disease or encephalopathy.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Volume68
Issue number6
DOIs
StatePublished - Jun 1 2019
Externally publishedYes

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Portal Hypertension
Hemorrhage
Platelet Count
Thrombocytopenia
Splenic Rupture
Pediatrics
Esophageal and Gastric Varices
Myelodysplastic Syndromes
Opportunistic Infections
Brain Diseases
Splenectomy
Population Characteristics
Abscess
Infarction
Abdominal Pain
Population
Liver Diseases
Fever
Spleen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Partial Splenic Embolization Is a Safe and Effective Alternative in the Management of Portal Hypertension in Children. / Vittorio, Jennifer; Orellana, Katherine; Martinez, Mercedes; Ovchinsky, Nadia; Schlossberg, Peter; Griesemer, Adam; Lobritto, Steven.

In: Journal of pediatric gastroenterology and nutrition, Vol. 68, No. 6, 01.06.2019, p. 793-798.

Research output: Contribution to journalArticle

Vittorio, Jennifer ; Orellana, Katherine ; Martinez, Mercedes ; Ovchinsky, Nadia ; Schlossberg, Peter ; Griesemer, Adam ; Lobritto, Steven. / Partial Splenic Embolization Is a Safe and Effective Alternative in the Management of Portal Hypertension in Children. In: Journal of pediatric gastroenterology and nutrition. 2019 ; Vol. 68, No. 6. pp. 793-798.
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AU - Griesemer, Adam

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