Parkinson's disease: Neuron loss in the nucleus basalis without concomitant Alzheimer's disease

Imaharu Nakano, Asao Hirano

Research output: Contribution to journalArticle

179 Scopus citations

Abstract

A representative region of the nucleus basalis of Meynert was investigated in 11 patients with idiopathic Parkinson's disease and compared with the identical region in 13 age‐matched control subjects. Simultaneously, the cerebral cortex and the nucleus basalis in the patients with Parkinson's disease were examined for senile plaques and Alzheimer's neurofibrillary tangles. The nucleus basalis was significantly depleted of its large neurons in Parkinson's disease (p < 0.001 versus controls; Student t test), but in the majority of cases the neuron loss was not associated with Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalAnnals of Neurology
Volume15
Issue number5
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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