TY - JOUR
T1 - Parkinson's disease and pesticides
T2 - Are microRNAs the missing link?
AU - Aloizou, Athina Maria
AU - Siokas, Vasileios
AU - Sapouni, Efstathia Maria
AU - Sita, Nikoleta
AU - Liampas, Ioannis
AU - Brotis, Alexandros G.
AU - Rakitskii, Valerii N.
AU - Burykina, Tatyana I.
AU - Aschner, Michael
AU - Bogdanos, Dimitrios P.
AU - Tsatsakis, Aristidis
AU - Hadjigeorgiou, Georgios M.
AU - Dardiotis, Efthimios
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/11/20
Y1 - 2020/11/20
N2 - Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, and among its pathogenic factors oxidative stress plays a critical role in disease progression. Pesticides are a broad class of chemicals widely used in agriculture and households for the protection of crops from insects and fungi. Several of them have been incriminated as risk factors for PD, but the underlying mechanisms have yet to be fully understood. MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in regulating mRNA translation and protein synthesis. miRNA levels have been shown to be affected in several diseases as well. Since the studies on the association between pesticides and PD have yet to reach definitive conclusions, here we review recent evidence on deregulated microRNAs upon pesticide exposure, and attempt to find an overlap between miRNAs deregulated in PD and pesticides, as a missing link between the two, and enhance future research in this direction.
AB - Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, and among its pathogenic factors oxidative stress plays a critical role in disease progression. Pesticides are a broad class of chemicals widely used in agriculture and households for the protection of crops from insects and fungi. Several of them have been incriminated as risk factors for PD, but the underlying mechanisms have yet to be fully understood. MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in regulating mRNA translation and protein synthesis. miRNA levels have been shown to be affected in several diseases as well. Since the studies on the association between pesticides and PD have yet to reach definitive conclusions, here we review recent evidence on deregulated microRNAs upon pesticide exposure, and attempt to find an overlap between miRNAs deregulated in PD and pesticides, as a missing link between the two, and enhance future research in this direction.
KW - MicroRNAs
KW - Neurotoxicity
KW - PD
KW - Parkinson's disease
KW - Pesticides
KW - miRNAs
UR - http://www.scopus.com/inward/record.url?scp=85088650647&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088650647&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2020.140591
DO - 10.1016/j.scitotenv.2020.140591
M3 - Review article
C2 - 32721662
AN - SCOPUS:85088650647
SN - 0048-9697
VL - 744
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 140591
ER -