Parental longevity and diabetes risk in the diabetes prevention program

Hermes Florez, Yong Ma, Jill P. Crandall, Leigh Perreault, Santica M. Marcovina, George A. Bray, Christopher D. Saudek, Elizabeth Barrett-Connor, William C. Knowler

Research output: Contribution to journalArticle

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Abstract

Background. Longevity clusters in families, and parental longevity may be associated with lower risk of chronic diseases in their children. It is unknown if diabetes risk is associated with parental longevity. Methods. We evaluated participants in the Diabetes Prevention Program with a parental history questionnaire at study entry. We classified them into five groups: premature death (parental death at age < 50 years), parental longevity (living to at least 80 years), and three intermediate groups (alive by age 49 but dying at age 50-59, 60-69, or 70-79). Those with alive parents and younger than 80 years were excluded. We analyzed separately effects of paternal (n = 2,165) and maternal (n = 1,739) longevity on diabetes incidence and risk after an average follow-up of 3.2 years.Results.At baseline, more diabetes risk factors (parental history of diabetes, coronary heart disease, higher body mass index, homeostasis model assessment for insulin resistance, and corrected insulin response) were found in participants whose parents died prematurely. Diabetes incidence was 9.5 cases/100 person-years in the 229 whose fathers died prematurely. In the 618 with paternal longevity, the rate was 6.6 cases/100 person-years (hazard ratio [95% confidence interval] = 0.68 [0.49-0.94]). The rates were 10.7 cases/100 person-years (n = 156) and 7.3 cases/100 person-years (n = 699, hazard ratio = 0.67 [95% confidence interval 0.47-0.95]) for those with maternal premature death or longevity, respectively. Associations with demographic and diabetes risk factors had minimal influence on the reduced risk found in those with paternal (adjusted hazard ratio = 0.78, 95% confidence interval 0.52-1.16) and maternal (adjusted hazard ratio = 0.64, 95% confidence interval 0.41-1.01) longevity. Conclusion. Parental longevity is associated with lower diabetes incidence in adults at high risk of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1211-1217
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume66 A
Issue number11
DOIs
StatePublished - Nov 2011

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Confidence Intervals
Premature Mortality
Incidence
Parental Death
Parents
Mothers
Maternal Death
Fathers
Type 2 Diabetes Mellitus
Coronary Disease
Insulin Resistance
Body Mass Index
Homeostasis
Chronic Disease
Age Groups
Demography
Insulin
Surveys and Questionnaires

Keywords

  • Diabetes Prevention Program
  • Diabetes risk
  • Parental longevity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Parental longevity and diabetes risk in the diabetes prevention program. / Florez, Hermes; Ma, Yong; Crandall, Jill P.; Perreault, Leigh; Marcovina, Santica M.; Bray, George A.; Saudek, Christopher D.; Barrett-Connor, Elizabeth; Knowler, William C.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 66 A, No. 11, 11.2011, p. 1211-1217.

Research output: Contribution to journalArticle

Florez, H, Ma, Y, Crandall, JP, Perreault, L, Marcovina, SM, Bray, GA, Saudek, CD, Barrett-Connor, E & Knowler, WC 2011, 'Parental longevity and diabetes risk in the diabetes prevention program', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, no. 11, pp. 1211-1217. https://doi.org/10.1093/gerona/glr114
Florez, Hermes ; Ma, Yong ; Crandall, Jill P. ; Perreault, Leigh ; Marcovina, Santica M. ; Bray, George A. ; Saudek, Christopher D. ; Barrett-Connor, Elizabeth ; Knowler, William C. / Parental longevity and diabetes risk in the diabetes prevention program. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2011 ; Vol. 66 A, No. 11. pp. 1211-1217.
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abstract = "Background. Longevity clusters in families, and parental longevity may be associated with lower risk of chronic diseases in their children. It is unknown if diabetes risk is associated with parental longevity. Methods. We evaluated participants in the Diabetes Prevention Program with a parental history questionnaire at study entry. We classified them into five groups: premature death (parental death at age < 50 years), parental longevity (living to at least 80 years), and three intermediate groups (alive by age 49 but dying at age 50-59, 60-69, or 70-79). Those with alive parents and younger than 80 years were excluded. We analyzed separately effects of paternal (n = 2,165) and maternal (n = 1,739) longevity on diabetes incidence and risk after an average follow-up of 3.2 years.Results.At baseline, more diabetes risk factors (parental history of diabetes, coronary heart disease, higher body mass index, homeostasis model assessment for insulin resistance, and corrected insulin response) were found in participants whose parents died prematurely. Diabetes incidence was 9.5 cases/100 person-years in the 229 whose fathers died prematurely. In the 618 with paternal longevity, the rate was 6.6 cases/100 person-years (hazard ratio [95{\%} confidence interval] = 0.68 [0.49-0.94]). The rates were 10.7 cases/100 person-years (n = 156) and 7.3 cases/100 person-years (n = 699, hazard ratio = 0.67 [95{\%} confidence interval 0.47-0.95]) for those with maternal premature death or longevity, respectively. Associations with demographic and diabetes risk factors had minimal influence on the reduced risk found in those with paternal (adjusted hazard ratio = 0.78, 95{\%} confidence interval 0.52-1.16) and maternal (adjusted hazard ratio = 0.64, 95{\%} confidence interval 0.41-1.01) longevity. Conclusion. Parental longevity is associated with lower diabetes incidence in adults at high risk of type 2 diabetes.",
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AU - Marcovina, Santica M.

AU - Bray, George A.

AU - Saudek, Christopher D.

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N2 - Background. Longevity clusters in families, and parental longevity may be associated with lower risk of chronic diseases in their children. It is unknown if diabetes risk is associated with parental longevity. Methods. We evaluated participants in the Diabetes Prevention Program with a parental history questionnaire at study entry. We classified them into five groups: premature death (parental death at age < 50 years), parental longevity (living to at least 80 years), and three intermediate groups (alive by age 49 but dying at age 50-59, 60-69, or 70-79). Those with alive parents and younger than 80 years were excluded. We analyzed separately effects of paternal (n = 2,165) and maternal (n = 1,739) longevity on diabetes incidence and risk after an average follow-up of 3.2 years.Results.At baseline, more diabetes risk factors (parental history of diabetes, coronary heart disease, higher body mass index, homeostasis model assessment for insulin resistance, and corrected insulin response) were found in participants whose parents died prematurely. Diabetes incidence was 9.5 cases/100 person-years in the 229 whose fathers died prematurely. In the 618 with paternal longevity, the rate was 6.6 cases/100 person-years (hazard ratio [95% confidence interval] = 0.68 [0.49-0.94]). The rates were 10.7 cases/100 person-years (n = 156) and 7.3 cases/100 person-years (n = 699, hazard ratio = 0.67 [95% confidence interval 0.47-0.95]) for those with maternal premature death or longevity, respectively. Associations with demographic and diabetes risk factors had minimal influence on the reduced risk found in those with paternal (adjusted hazard ratio = 0.78, 95% confidence interval 0.52-1.16) and maternal (adjusted hazard ratio = 0.64, 95% confidence interval 0.41-1.01) longevity. Conclusion. Parental longevity is associated with lower diabetes incidence in adults at high risk of type 2 diabetes.

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KW - Diabetes Prevention Program

KW - Diabetes risk

KW - Parental longevity

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