Parathyroid gland morphology in nonparathyroid hormone-mediated hypercalcemia

D. R. Dufour, S. J. Marx, Allen M. Spiegel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Occasionally, patients with other causes of hypercalcemia undergo parathyroidectomy for suspected primary hyperparathyroidism. We studied the parathyroid glands from 12 persons with nonparathyroid hypercalcemia. Glands from these individuals were similar to normal glands in size and fat:parenchymal ratio, showing neither atrophy nor hyperplasia. A distinctive histologic feature, also seen in hyperparathyroid hypercalcemia, is the presence of pale, vacuolated cells arranged in a trabecular pattern. Recognition of normal parathyroid parenchymal weight and the nonspecific nature of these vacuolated cells is necessary to prevent false-positive diagnoses of parathyroid hyperplasia. For glands which have not been weighed, parenchymal cross-sectional area can only be used as a rough index of parenchymal weight.

Original languageEnglish (US)
Pages (from-to)43-51
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume9
Issue number1
StatePublished - 1985
Externally publishedYes

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Parathyroid Glands
Hypercalcemia
Hormones
Hyperplasia
Weights and Measures
Parathyroidectomy
Primary Hyperparathyroidism
Atrophy
Fats

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Parathyroid gland morphology in nonparathyroid hormone-mediated hypercalcemia. / Dufour, D. R.; Marx, S. J.; Spiegel, Allen M.

In: American Journal of Surgical Pathology, Vol. 9, No. 1, 1985, p. 43-51.

Research output: Contribution to journalArticle

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