Paraneoplastic Seronegative Pauci-Immune Glomerulonephritis Associated with Lung Adenocarcinoma Responds to Rituximab: A Case Report

Pragnan Kancharla, B. K. Surapaneni, M. Goldfinger, K. Hennrick, David J. Ozeri

Research output: Contribution to journalArticle

Abstract

Anti-neutrophil cytoplasmic antibodies (ANCA) play an important role in the pathogenesis of pauci-immune renal vasculitis. However, in 10% of the cases, ANCA are absent. We present a case of a 64-year-old man with a chronic untreated hepatitis C virus infection and Middle Eastern thalassemia who was ANCA-negative when he was hospitalized due to acute kidney injury and accounts for an uncommon presentation of renal vasculitis. The patient had earlier reported to have undergone local lobectomy and adjuvant chemotherapy (carboplatin/pemetrexed) for lung adenocarcinoma a month prior. IL-6 has been reported to be involved in the pathophysiological cascade causing pauci-immune glomerulonephritis amongst non-small cell lung cancer patients. Previous studies with subgroup analysis have demonstrated that ANCA negativity has been associated with more chronic glomerular lesions and less crescent formation, which tends to have a critical outcome in the renal system. However, our patient underwent kidney biopsy exhibiting active crescentic glomerulonephritis, pauci-immune type with 5 cellular crescents amongst 15 glomeruli. To our knowledge, this is the third reported case of ANCA-negative vasculitis with typical presentation on biopsy in non-small cell lung cancer patients.

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalCase Reports in Oncology
Volume11
Issue number2
DOIs
StatePublished - May 1 2018
Externally publishedYes

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Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Kidney
Vasculitis
Non-Small Cell Lung Carcinoma
Pemetrexed
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Biopsy
Thalassemia
Carboplatin
Chronic Hepatitis C
Virus Diseases
Adjuvant Chemotherapy
Acute Kidney Injury
Hepacivirus
Interleukin-6
Adenocarcinoma of lung
Rituximab

Keywords

  • Lung adenocarcinoma
  • Paraneoplastic seronegative pauci-immune glomerulonephritis

ASJC Scopus subject areas

  • Oncology

Cite this

Paraneoplastic Seronegative Pauci-Immune Glomerulonephritis Associated with Lung Adenocarcinoma Responds to Rituximab : A Case Report. / Kancharla, Pragnan; Surapaneni, B. K.; Goldfinger, M.; Hennrick, K.; Ozeri, David J.

In: Case Reports in Oncology, Vol. 11, No. 2, 01.05.2018, p. 372-377.

Research output: Contribution to journalArticle

Kancharla, Pragnan ; Surapaneni, B. K. ; Goldfinger, M. ; Hennrick, K. ; Ozeri, David J. / Paraneoplastic Seronegative Pauci-Immune Glomerulonephritis Associated with Lung Adenocarcinoma Responds to Rituximab : A Case Report. In: Case Reports in Oncology. 2018 ; Vol. 11, No. 2. pp. 372-377.
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